Expression of LL-37/hCAP-18 gene in human leukemia cells

Ying Hua Yang, Guo Guang Zheng, Ge Li, Bin Zhang, Yu Hua Song, Ke Fu Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

LL-37/hCAP-18 is an important part of host defense. Several diseases in human are characterized by impairment in the function of LL-37/hCAP-18 peptide. We examined the expression of LL-37/hCAP-18 in a panel of hematopoietic cell lines representing multiple cell lineages. LL-37/hCAP-18 expression at mRNA level was detected and varied among six of nine cell lines. The level of Raji cells was about eight folds higher than that of Ramos cells. However, only two cell lines, J6-1 and U937, expressed protein products. We also investigated LL-37/hCAP-18 protein in nine leukemia and three idiopathic thrombocytopenic purpura (ITP) patients via immunocytochemical staining. The rate of LL-37/hCAP-18 positive cells ranged from 60 (ITP) to 0.5% (M5). These data suggested that the low translation efficiency of LL-37/hCAP-18 expresses in some leukemia cells might be one of the reasons that leukemia patients were susceptible to infection.

Original languageEnglish (US)
Pages (from-to)947-950
Number of pages4
JournalLeukemia Research
Volume27
Issue number10
DOIs
StatePublished - Oct 1 2003

Keywords

  • Innate immunity
  • LL-37
  • Leukemia cell
  • hCAP-18

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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