Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development

Xin Geng; Alfonso Lavado; Oleg V. Lagutin; Wei Liu; Guillermo Oliver

doi:10.1016/j.modgep.2006.09.007

Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development

Xin Geng, Alfonso Lavado, Oleg V. Lagutin, Wei Liu, Guillermo Oliver^*

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Recently, sequence analyses have identified a large number of opposite strand transcripts in the vertebrate genome. Although the transcripts appear to be spliced and polyadenylated, many of them are predicted to represent noncoding RNAs. High levels of noncoding transcripts of the Six3 Opposite Strand (Six3OS) were recently identified in the embryonic and postnatal retina of the mouse. In this study, we expanded those initial expression analyses, elucidated in detail the developmental expression profile of mouse Six3OS in the brain and visual system, and compared it with that of Six3. Our results show that Six3OS expression overlaps extensively with that of Six3 and is not altered in Six3-null embryos.

Original language	English (US)
Pages (from-to)	252-257
Number of pages	6
Journal	Gene Expression Patterns
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/j.modgep.2006.09.007
State	Published - Jan 2 2007

Keywords

Brain development
Expression analysis
Homeobox
Mouse
Six3
Six3OS

ASJC Scopus subject areas

Genetics
Molecular Biology
Developmental Biology

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10.1016/j.modgep.2006.09.007

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title = "Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development",

abstract = "Recently, sequence analyses have identified a large number of opposite strand transcripts in the vertebrate genome. Although the transcripts appear to be spliced and polyadenylated, many of them are predicted to represent noncoding RNAs. High levels of noncoding transcripts of the Six3 Opposite Strand (Six3OS) were recently identified in the embryonic and postnatal retina of the mouse. In this study, we expanded those initial expression analyses, elucidated in detail the developmental expression profile of mouse Six3OS in the brain and visual system, and compared it with that of Six3. Our results show that Six3OS expression overlaps extensively with that of Six3 and is not altered in Six3-null embryos.",

keywords = "Brain development, Expression analysis, Homeobox, Mouse, Six3, Six3OS",

author = "Xin Geng and Alfonso Lavado and Lagutin, {Oleg V.} and Wei Liu and Guillermo Oliver",

note = "Funding Information: We thank P. Gruss for the α-Cre mice. We also thank L. Solnica-Kretzel and A. Inbal for discussions, and M. Dillard for reading of the manuscript. This work was supported in part by NIH Grants EY12162 and NS052386 to G.O., Cancer Center Support Grant CA-21765, and the American Lebanese Syrian Associated Charities (ALSAC).",

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T1 - Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development

AU - Geng, Xin

AU - Lavado, Alfonso

AU - Lagutin, Oleg V.

AU - Liu, Wei

AU - Oliver, Guillermo

N1 - Funding Information: We thank P. Gruss for the α-Cre mice. We also thank L. Solnica-Kretzel and A. Inbal for discussions, and M. Dillard for reading of the manuscript. This work was supported in part by NIH Grants EY12162 and NS052386 to G.O., Cancer Center Support Grant CA-21765, and the American Lebanese Syrian Associated Charities (ALSAC).

PY - 2007/1/2

Y1 - 2007/1/2

N2 - Recently, sequence analyses have identified a large number of opposite strand transcripts in the vertebrate genome. Although the transcripts appear to be spliced and polyadenylated, many of them are predicted to represent noncoding RNAs. High levels of noncoding transcripts of the Six3 Opposite Strand (Six3OS) were recently identified in the embryonic and postnatal retina of the mouse. In this study, we expanded those initial expression analyses, elucidated in detail the developmental expression profile of mouse Six3OS in the brain and visual system, and compared it with that of Six3. Our results show that Six3OS expression overlaps extensively with that of Six3 and is not altered in Six3-null embryos.

AB - Recently, sequence analyses have identified a large number of opposite strand transcripts in the vertebrate genome. Although the transcripts appear to be spliced and polyadenylated, many of them are predicted to represent noncoding RNAs. High levels of noncoding transcripts of the Six3 Opposite Strand (Six3OS) were recently identified in the embryonic and postnatal retina of the mouse. In this study, we expanded those initial expression analyses, elucidated in detail the developmental expression profile of mouse Six3OS in the brain and visual system, and compared it with that of Six3. Our results show that Six3OS expression overlaps extensively with that of Six3 and is not altered in Six3-null embryos.

KW - Brain development

KW - Expression analysis

KW - Homeobox

KW - Mouse

KW - Six3

KW - Six3OS

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Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development

Abstract

Keywords

ASJC Scopus subject areas

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