Expression of the Double-Stranded RNA-Dependent Protein Kinase (p68) in Squamous Cell Carcinoma of the Head and Neck Region

G. Kenneth Haines, Stephen Becker, Ghanashaym Ghadge, Merrill Kies, Harold Pelzer, James Radosevich

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

p68 is an interferon-inducible protein kinase that is believed to be an important factor in the regulation of both viral and cellular protein synthesis. We have previously shown that p68 expression correlates with differentiation in a variety of tumors, including squamous cell carcinoma of the head and neck region. The current study aims to identify the prognostic significance of p68 expression in squamous cell carcinoma of the head and neck. Archival material from a cohort of 75 patients with primary squamous carcinomas of the head and neck was immunostained for p68 with the monoclonal antibody TJ4C4. Overall scores for p68 expression were tabulated based on staining intensity and percentage of immunoreactive tumor cells. Clinical information including tumor grade, stage, site, treatment, disease-free, and total survival was tabulated and compared by p68 expression group. Veterans Administration Lakeside Medical Center and outpatient clinics (Northwestern University and Veterans Administration Lakeside Medical Center, Chicago, Ill). Seventy-five consecutive patients with primary squamous cell carcinoma of the head and neck (excluding the esophagus), with tissue blocks available for study, a known primary site, no history of prior carcinoma, and demographic and follow-up information available. Disease-free and overall survival rates. While there was a wide range of outcomes within each group, as a group, high levels of p68 expression correlated with a lower incidence of recurrent or residual disease and longer disease-free and total survival times compared with groups with lower levels of p68 expression. These differences could not be explained on differences in patient age, tumor grade, and TNM stage. High-level p68 expression is associated with prolonged disease-free and overall survival in a series of patients with squamous cell carcinoma of the head and neck region. Additional study is needed to monitor changes in p68 expression with treatment or tumor progression.

Original languageEnglish (US)
Pages (from-to)1142-1147
Number of pages6
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume119
Issue number10
DOIs
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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