Abstract
The MUC 6 mucin cDNA was isolated from a human stomach cDNA library and has been shown to be expressed in a number of other tissues in the gastrointestinal tract, including the gallbladder, pancreas, and parts of the ileum and colon. Here we establish that MUC 6 is expressed transiently in the nephrogenic zone of the kidney in the early midtrimester of development. MUC 6 transcripts were detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation. Traces of MUC 6 mRNA were seen in the collecting ducts but not elsewhere in the developing kidney, and MUC 6 glycoprotein was detected in the epithelium of ureteric buds and collecting ducts. MUC 6 transcripts were absent from adult kidney. This pattern of expression of MUC 6 in the developing kidney suggests a role in epithelial organogenesis. MUC 6 transcripts were also present at low levels in mid-trimester epididymal epithelium.
Original language | English (US) |
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Pages (from-to) | 817-821 |
Number of pages | 5 |
Journal | Journal of Histochemistry and Cytochemistry |
Volume | 47 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1999 |
Keywords
- Kidney development
- MUC 6
- Mucin
ASJC Scopus subject areas
- Anatomy
- Histology