Expression of the sodium channel β1 subunit in rat skeletal muscle is selectively associated with the tetrodotoxin-sensitive α subunit isoform

Jane S. Yang*, Paul B. Bennett, Naomasa Makita, Alfred L. George, Robert L. Barchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Transcripts homologous to the rat brain sodium channel β subunit (β1) are prominently expressed in both innervated and denervated adult skeletal muscle and in heart, but not in neonatal skeletal or cardiac muscle. Regulation of β1 mRNA expression closely parallels that of SkM1 α during development, after denervation in adult muscle, and in primary muscle culture, but does not follow SkM2 expression under any condition examined. In oocytes, β1 interacts functionally with SkM1 to modulate the abnormally slow inactivation kinetics observed with this α subunit expressed alone. We conclude that a common β1, subunit is expressed in skeletal muscle, heart, and brain and that in skeletal muscle, this subunit is specifically associated with the SkM1, rather than the SkM2, sodium channel isoform.

Original languageEnglish (US)
Pages (from-to)915-922
Number of pages8
JournalNeuron
Volume11
Issue number5
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Neuroscience(all)

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