Extended-spectrum β-lactamase-producing enterobacteriaceae in children: Old foe, emerging threat

Paul J. Lukac, Robert A. Bonomo, Latania K. Logan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae present an ever-growing burden in the hospital and community settings, across all ages and demographics. Infections due to ESBL-containing pathogens continue to be associated with significant morbidity and mortality worldwide. With widespread empiric broad-spectrum β-lactam use creating selective pressure, and the resultant emergence of stable, rapidly proliferating ESBL-producing clones with continued horizontal gene transfer across genera, addressing this issue remains imperative. Although well characterized in adults, the epidemiology, risk factors, outcomes, therapies, and control measures for ESBL-producing bacteria are less appreciated in children. This analysis provides a brief summary of ESBL-producing Enterobacteriaceae in children, with a focus on recent clinical and molecular data regarding colonization and infection in nonoutbreak settings.

Original languageEnglish (US)
Pages (from-to)1389-1397
Number of pages9
JournalClinical Infectious Diseases
Volume60
Issue number9
DOIs
StatePublished - May 1 2015

Keywords

  • Child
  • Drug resistance
  • Enterobacteriaceae infections
  • Epidemiology
  • β-lactamases

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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