TY - JOUR
T1 - Extensive migration of young neurons into the infant human frontal lobe
AU - Paredes, Mercedes F.
AU - James, David
AU - Gil-Perotin, Sara
AU - Kim, Hosung
AU - Cotter, Jennifer A.
AU - Ng, Carissa
AU - Sandoval, Kadellyn
AU - Rowitch, David H.
AU - Xu, Duan
AU - McQuillen, Patrick S.
AU - Garcia-Verdugo, Jose Manuel
AU - Huang, Eric J.
AU - Alvarez-Buylla, Arturo
N1 - Funding Information:
We thank the families who graciously donated the tissue samples used in this study; H.-H. Tsai, T. Nowakowski, K. Obernier, J. Barkovich, and L. Submaranian for experimental advice; J. Elsbernd and J. Che for technical support; and M. Kohn for statistical input. Supported by NIH grants RO1 HD032116-21 (A.A.-B.), PO1 NS083513-02 (A.A.-B., E.J.H., and D.H.R.), R01EB009756 and R01HD072074 (D.X.), MBRS-RISE R25-GM059298 (D.J.), K08NS091537-01A1 (M.F.P.), and 2R01 NS060896 (P.S.M.); California Institute of Regenerative Medicine grants TG-01153 (M.F.P.) and TB1-01194 (D.J.); Spanish Institute of Health Carlos III grant ISCIII2012-RD19-016 (J.-M.G.-V.); Rio Hortega fellowship CM12/00014 (S.G.-P.); Banting and FRS Canadian fellowships (H.K.); and Economics and Competitivity Ministry of Spain grant BFU2015-64207-P and Generalitat Valenciana grant PrometeoII 2014-075. Supplement contains additional data. A.A.-B. is on the scientific advisory board and is co-founder of Neurona Therapeutics.
Publisher Copyright:
© 2016, American Association for the Advancement of Science. All rights reserved.
PY - 2016/10/7
Y1 - 2016/10/7
N2 - The first few months after birth, when a child begins to interact with the environment, are critical to human brain development. The human frontal lobe is important for social behavior and executive function; it has increased in size and complexity relative to other species, but the processes that have contributed to this expansion are unknown. Our studies of postmortem infant human brains revealed a collection of neurons that migrate and integrate widely into the frontal lobe during infancy. Chains of young neurons move tangentially close to the walls of the lateral ventricles and along blood vessels. These cells then individually disperse long distances to reach cortical tissue, where they differentiate and contribute to inhibitory circuits. Late-arriving interneurons could contribute to developmental plasticity, and the disruption of their postnatal migration or differentiation may underlie neurodevelopmental disorders.
AB - The first few months after birth, when a child begins to interact with the environment, are critical to human brain development. The human frontal lobe is important for social behavior and executive function; it has increased in size and complexity relative to other species, but the processes that have contributed to this expansion are unknown. Our studies of postmortem infant human brains revealed a collection of neurons that migrate and integrate widely into the frontal lobe during infancy. Chains of young neurons move tangentially close to the walls of the lateral ventricles and along blood vessels. These cells then individually disperse long distances to reach cortical tissue, where they differentiate and contribute to inhibitory circuits. Late-arriving interneurons could contribute to developmental plasticity, and the disruption of their postnatal migration or differentiation may underlie neurodevelopmental disorders.
UR - http://www.scopus.com/inward/record.url?scp=84990201884&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990201884&partnerID=8YFLogxK
U2 - 10.1126/science.aaf7073
DO - 10.1126/science.aaf7073
M3 - Article
C2 - 27846470
AN - SCOPUS:84990201884
VL - 354
JO - Science
JF - Science
SN - 0036-8075
IS - 6308
M1 - aaf7073
ER -