Extracellular matrix, inflammation, and the angiogenic response

Alicia G. Arroyo, M. Luisa Iruela-Arispe

Research output: Contribution to journalReview articlepeer-review

192 Scopus citations

Abstract

Inflammation and angiogenesis are frequently coupled in pathological situations such as atherosclerosis, diabetes, and arthritis. The inflammatory response increases capillary permeability and induces endothelial activation, which, when persistent, results in capillary sprouting. This inflammation-induced angiogenesis and the subsequent remodelling steps are in large part mediated by extracellular matrix (ECM) proteins and proteases. The focal increase in capillary permeability is an early consequence of inflammation, and results in the deposition of a provisional fibrin matrix. Subsequently, ECM turnover by proteases permits an invasive program by specialized endothelial cells whose phenotype can be regulated by inflammatory stimuli. ECM activity also provides specific mechanical forces, exposes cryptic adhesion sites, and releases biologically active fragments (matrikines) and matrix-sequestered growth factors, all of which are critical for vascular morphogenesis. Further matrix remodelling and vascular regression contribute to the resolution of the inflammatory response and facilitate tissue repair.

Original languageEnglish (US)
Pages (from-to)226-235
Number of pages10
JournalCardiovascular research
Volume86
Issue number2
DOIs
StatePublished - May 2010

Keywords

  • Angiogenesis
  • Extracellular matrix
  • Growth factors
  • Inflammation
  • Proteases

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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