Extracellular stimulation of mouse retinal ganglion cells with non-rectangular voltage-controlled waveforms

Donald R. Cantrell, John B. Troy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Abstract

Neural prostheses rely upon electric stimulation to control neural activity. However, electrode corrosion and tissue damage may result from the injection of high charge densities. During electrical stimulation with traditional voltage-controlled square-wave pulses, the current density distribution on the surface of the stimulating electrode is highly nonuniform, with the highest current densities located at the edge of disk-shaped electrodes. Current density is implicated in tissue damage and electrode corrosion because it determines the charge density distribution. Through recent computer modeling work, we have found that Gaussian and sinusoidal stimulus waveforms produce a current density distribution that is significantly more uniform than the one produced by square-wave pulses. In this manner, these non-rectangular waveforms reduce the peak current densities without decreasing the efficacy of the neural stimulus. In the present work, we utilize an in vitro mouse retinal preparation to compare the same set of alternative stimulus waveforms. The -1V amplitude voltage-controlled stimuli were delivered through 20 μm diameter titanium nitride electrodes. Importantly, when normalized for the amount of injected charge, the data demonstrate that each waveform is similarly effective at eliciting a neural response. Also, the suprathreshold Gaussian and sinusoidal waveforms possessed much lower peaks in current. For this reason, these non-rectangular waveforms may be useful in reducing electrode corrosion and tissue damage.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages642-645
Number of pages4
ISBN (Print)9781424432967
DOIs
StatePublished - Jan 1 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Publication series

NameProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

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