Extracellular transport of cell-size particles and tumor cells by dendritic cells in culture

Robert I. Thacker, Andrew C. Retzinger, James G. Cash, Michael D. Dentler, Gregory S. Retzinger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Many particulate materials of sizes approximating that of a cell disseminate after being introduced into the body. While some move about within phagocytic inflammatory cells, others appear to move about outside of, but in contact with, such cells. In this report, we provide unequivocal photomicroscopic evidence that cultured, mature, human dendritic cells can transport in extracellular fashion over significant distances both polymeric beads and tumor cells. At least in the case of polymeric beads, both fibrinogen and the β2-integrin subunit, CD18, appear to play important roles in the transport process. These discoveries may yield insight into a host of disease-related phenomena, including and especially tumor cell invasion and metastasis.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalExperimental and Molecular Pathology
Volume95
Issue number3
DOIs
StatePublished - Dec 2013

Keywords

  • Cancer
  • Cell-size particles
  • Chemotaxis
  • Dendritic cells
  • Directed migration
  • Extracellular transport
  • Inflammation
  • Metastasis
  • Tumor cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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