Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A

Ravi R. Thiagarajan; Stephen J. Roth; Steven Margossian; Andrew S. Mackie; Ellis J. Neufeld; Peter C. Laussen; Joseph M. Forbess; Elizabeth D. Blume

doi:10.1007/s00134-003-1748-5

Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A

Ravi R. Thiagarajan^*, Stephen J. Roth, Steven Margossian, Andrew S. Mackie, Ellis J. Neufeld, Peter C. Laussen, Joseph M. Forbess, Elizabeth D. Blume

^*Corresponding author for this work

Surgery, Cardiac Surgery Division

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: To report the use of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation in a patient with hemophilia A and dilated cardiomyopathy. Design: Case report. Interventions and results: During ECMO factor VIII concentrate was administered to maintain a factor VIII level close to 50% of normal control both to decrease the risk of bleeding and to allow standard anticoagulation with heparin. The patient developed an inhibitor to exogenous factor VIII during hospitalization, which was successfully managed with a high-dose continuous infusion of factor VIII during ECMO, the transplant operation, and the postoperative period. Conclusions: We report the successful use of ECMO as a bridge to cardiac transplantation in a patient with hemophilia A and low-level factor VIII inhibitors.

Original language	English (US)
Pages (from-to)	985-988
Number of pages	4
Journal	Intensive Care Medicine
Volume	29
Issue number	6
DOIs	https://doi.org/10.1007/s00134-003-1748-5
State	Published - Jun 1 2003

Funding

This work was supported in part by grant HL04183-03 from the NIH to E.J.N.

Keywords

Cardiac transplantation
Dilated cardiomyopathy
Extracorporeal membrane oxygenation
Factor VIII inhibitor
Hemophilia A

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1007/s00134-003-1748-5

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@article{7891358272404162a6cd1e7592fe6865,

title = "Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A",

abstract = "Objective: To report the use of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation in a patient with hemophilia A and dilated cardiomyopathy. Design: Case report. Interventions and results: During ECMO factor VIII concentrate was administered to maintain a factor VIII level close to 50% of normal control both to decrease the risk of bleeding and to allow standard anticoagulation with heparin. The patient developed an inhibitor to exogenous factor VIII during hospitalization, which was successfully managed with a high-dose continuous infusion of factor VIII during ECMO, the transplant operation, and the postoperative period. Conclusions: We report the successful use of ECMO as a bridge to cardiac transplantation in a patient with hemophilia A and low-level factor VIII inhibitors.",

keywords = "Cardiac transplantation, Dilated cardiomyopathy, Extracorporeal membrane oxygenation, Factor VIII inhibitor, Hemophilia A",

author = "Thiagarajan, {Ravi R.} and Roth, {Stephen J.} and Steven Margossian and Mackie, {Andrew S.} and Neufeld, {Ellis J.} and Laussen, {Peter C.} and Forbess, {Joseph M.} and Blume, {Elizabeth D.}",

note = "Funding Information: This work was supported in part by grant HL04183-03 from the NIH to E.J.N.",

year = "2003",

month = jun,

day = "1",

doi = "10.1007/s00134-003-1748-5",

language = "English (US)",

volume = "29",

pages = "985--988",

journal = "Intensive Care Medicine",

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TY - JOUR

T1 - Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A

AU - Thiagarajan, Ravi R.

AU - Roth, Stephen J.

AU - Margossian, Steven

AU - Mackie, Andrew S.

AU - Neufeld, Ellis J.

AU - Laussen, Peter C.

AU - Forbess, Joseph M.

AU - Blume, Elizabeth D.

N1 - Funding Information: This work was supported in part by grant HL04183-03 from the NIH to E.J.N.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Objective: To report the use of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation in a patient with hemophilia A and dilated cardiomyopathy. Design: Case report. Interventions and results: During ECMO factor VIII concentrate was administered to maintain a factor VIII level close to 50% of normal control both to decrease the risk of bleeding and to allow standard anticoagulation with heparin. The patient developed an inhibitor to exogenous factor VIII during hospitalization, which was successfully managed with a high-dose continuous infusion of factor VIII during ECMO, the transplant operation, and the postoperative period. Conclusions: We report the successful use of ECMO as a bridge to cardiac transplantation in a patient with hemophilia A and low-level factor VIII inhibitors.

AB - Objective: To report the use of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation in a patient with hemophilia A and dilated cardiomyopathy. Design: Case report. Interventions and results: During ECMO factor VIII concentrate was administered to maintain a factor VIII level close to 50% of normal control both to decrease the risk of bleeding and to allow standard anticoagulation with heparin. The patient developed an inhibitor to exogenous factor VIII during hospitalization, which was successfully managed with a high-dose continuous infusion of factor VIII during ECMO, the transplant operation, and the postoperative period. Conclusions: We report the successful use of ECMO as a bridge to cardiac transplantation in a patient with hemophilia A and low-level factor VIII inhibitors.

KW - Cardiac transplantation

KW - Dilated cardiomyopathy

KW - Extracorporeal membrane oxygenation

KW - Factor VIII inhibitor

KW - Hemophilia A

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U2 - 10.1007/s00134-003-1748-5

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SN - 0342-4642

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JO - Intensive Care Medicine

JF - Intensive Care Medicine

IS - 6

ER -

Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A

Abstract

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Keywords

ASJC Scopus subject areas

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