Extravasation of calcium gluconate as a cause of soft tissue calcification in infancy

Three cases of soft tissue calcification secondary to subcutaneous extravasation of an intravenous infusion of calcium gluconate are reported. Histologic changes consist of thickening of the subcutaneum and calcification in the subcutaneum and the fascial planes. Vascular calcification may also be seen. Radiologic recognition and awareness of this diagnosis is important, as the clinical picture is variable and the etiology of the presenting inflammatory response or mass is often unknown.