Eye movement performance and clinical outcomes among female athletes post-concussion

Virginia Gallagher; Brian Vesci; Jeffrey Mjaanes; Hans Breiter; Yufen Chen; Amy Herrold; James Reilly

doi:10.1080/02699052.2020.1830173

Eye movement performance and clinical outcomes among female athletes post-concussion

Virginia Gallagher^*, Brian Vesci, Jeffrey Mjaanes, Hans Breiter, Yufen Chen, Amy Herrold, James Reilly

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Most post-concussion eye movement (EM) research involves predominantly male samples. We evaluated pro- (PRO; reflexive shift of visual attention to target) and anti- (ANTI; executive control of visual attention away from target) computer-based saccade task performance among female, collegiate athletes with recent concussion (CON) versus healthy-control athletes (HC). We evaluated the relationship between EM performance and post-concussion outcomes. We hypothesized ANTI performance would differ among CON and HC due to greater executive control demands, and that EM performance (both tasks) would be associated with clinical outcomes in CON. Methods: 16 CON (assessed 4–10 days post-injury [M = 6.87, SD = 2.15 days]) and 16 age-matched HC athletes were recruited. General linear mixed modeling and Pearson’s correlations were used. Results: On ANTI, CON demonstrated higher error rate [F(1,2863) = 12.650, p<.001] and shorter latency on error trials [F(1,469) = 5.976, p=.015] relative to HC. Multiple EM measures were associated with clinical outcomes: PRO duration predicted days to symptom remission (r=.44, p <.05); ANTI error rate was associated with symptom burden on the day of testing (r=.27, p <.05). Conclusion: This study demonstrates promising utility of EM measures to detect cognitive control and sensorimotor effects of concussion among female athletes and their use as a prognostic indicators of recovery.

Original language	English (US)
Pages (from-to)	1674-1684
Number of pages	11
Journal	Brain Injury
Volume	34
Issue number	12
DOIs	https://doi.org/10.1080/02699052.2020.1830173
State	Published - Oct 14 2020

Funding

This work was funded by the Eleanor Wood-Prince Grant Initiative: A Project of the Woman’s Board of Northwestern Memorial Hospital, the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number F31NS106840, and data collection via REDCap was supported in part by a Clinical and Translational Science Award (CTSA) grant from the National Institutes of Health (NIH) under Award Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Support for Drs. Hans Breiter and James Reilly was also supplied by the Northwestern University Warren Wright Adolescent Center. This work was supported by the National Institute of Neurological Disorders and Stroke [F31NS106840]; National Institutes of Health [UL1TR001422]; Eleanor Wood-Prince Grant Initiative: Women?s Board of Northwestern Memorial Hospital; Warren Wright Adolescent Center.

Keywords

Sports-related concussion
eye movement
oculomotor
saccade

ASJC Scopus subject areas

Clinical Neurology
Developmental and Educational Psychology
Neuroscience (miscellaneous)

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10.1080/02699052.2020.1830173

Cite this

@article{135c7de32c054487a941c2796b6e0478,

title = "Eye movement performance and clinical outcomes among female athletes post-concussion",

abstract = "Background: Most post-concussion eye movement (EM) research involves predominantly male samples. We evaluated pro- (PRO; reflexive shift of visual attention to target) and anti- (ANTI; executive control of visual attention away from target) computer-based saccade task performance among female, collegiate athletes with recent concussion (CON) versus healthy-control athletes (HC). We evaluated the relationship between EM performance and post-concussion outcomes. We hypothesized ANTI performance would differ among CON and HC due to greater executive control demands, and that EM performance (both tasks) would be associated with clinical outcomes in CON. Methods: 16 CON (assessed 4–10 days post-injury [M = 6.87, SD = 2.15 days]) and 16 age-matched HC athletes were recruited. General linear mixed modeling and Pearson{\textquoteright}s correlations were used. Results: On ANTI, CON demonstrated higher error rate [F(1,2863) = 12.650, p<.001] and shorter latency on error trials [F(1,469) = 5.976, p=.015] relative to HC. Multiple EM measures were associated with clinical outcomes: PRO duration predicted days to symptom remission (r=.44, p <.05); ANTI error rate was associated with symptom burden on the day of testing (r=.27, p <.05). Conclusion: This study demonstrates promising utility of EM measures to detect cognitive control and sensorimotor effects of concussion among female athletes and their use as a prognostic indicators of recovery.",

keywords = "Sports-related concussion, eye movement, oculomotor, saccade",

author = "Virginia Gallagher and Brian Vesci and Jeffrey Mjaanes and Hans Breiter and Yufen Chen and Amy Herrold and James Reilly",

note = "Funding Information: This work was funded by the Eleanor Wood-Prince Grant Initiative: A Project of the Woman{\textquoteright}s Board of Northwestern Memorial Hospital, the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number F31NS106840, and data collection via REDCap was supported in part by a Clinical and Translational Science Award (CTSA) grant from the National Institutes of Health (NIH) under Award Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Support for Drs. Hans Breiter and James Reilly was also supplied by the Northwestern University Warren Wright Adolescent Center. Funding Information: This work was supported by the National Institute of Neurological Disorders and Stroke [F31NS106840]; National Institutes of Health [UL1TR001422]; Eleanor Wood-Prince Grant Initiative: Women?s Board of Northwestern Memorial Hospital; Warren Wright Adolescent Center. Publisher Copyright: {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2020",

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doi = "10.1080/02699052.2020.1830173",

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T1 - Eye movement performance and clinical outcomes among female athletes post-concussion

AU - Gallagher, Virginia

AU - Vesci, Brian

AU - Mjaanes, Jeffrey

AU - Breiter, Hans

AU - Chen, Yufen

AU - Herrold, Amy

AU - Reilly, James

N1 - Funding Information: This work was funded by the Eleanor Wood-Prince Grant Initiative: A Project of the Woman’s Board of Northwestern Memorial Hospital, the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number F31NS106840, and data collection via REDCap was supported in part by a Clinical and Translational Science Award (CTSA) grant from the National Institutes of Health (NIH) under Award Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Support for Drs. Hans Breiter and James Reilly was also supplied by the Northwestern University Warren Wright Adolescent Center. Funding Information: This work was supported by the National Institute of Neurological Disorders and Stroke [F31NS106840]; National Institutes of Health [UL1TR001422]; Eleanor Wood-Prince Grant Initiative: Women?s Board of Northwestern Memorial Hospital; Warren Wright Adolescent Center. Publisher Copyright: © 2020 Taylor & Francis Group, LLC.

PY - 2020/10/14

Y1 - 2020/10/14

N2 - Background: Most post-concussion eye movement (EM) research involves predominantly male samples. We evaluated pro- (PRO; reflexive shift of visual attention to target) and anti- (ANTI; executive control of visual attention away from target) computer-based saccade task performance among female, collegiate athletes with recent concussion (CON) versus healthy-control athletes (HC). We evaluated the relationship between EM performance and post-concussion outcomes. We hypothesized ANTI performance would differ among CON and HC due to greater executive control demands, and that EM performance (both tasks) would be associated with clinical outcomes in CON. Methods: 16 CON (assessed 4–10 days post-injury [M = 6.87, SD = 2.15 days]) and 16 age-matched HC athletes were recruited. General linear mixed modeling and Pearson’s correlations were used. Results: On ANTI, CON demonstrated higher error rate [F(1,2863) = 12.650, p<.001] and shorter latency on error trials [F(1,469) = 5.976, p=.015] relative to HC. Multiple EM measures were associated with clinical outcomes: PRO duration predicted days to symptom remission (r=.44, p <.05); ANTI error rate was associated with symptom burden on the day of testing (r=.27, p <.05). Conclusion: This study demonstrates promising utility of EM measures to detect cognitive control and sensorimotor effects of concussion among female athletes and their use as a prognostic indicators of recovery.

AB - Background: Most post-concussion eye movement (EM) research involves predominantly male samples. We evaluated pro- (PRO; reflexive shift of visual attention to target) and anti- (ANTI; executive control of visual attention away from target) computer-based saccade task performance among female, collegiate athletes with recent concussion (CON) versus healthy-control athletes (HC). We evaluated the relationship between EM performance and post-concussion outcomes. We hypothesized ANTI performance would differ among CON and HC due to greater executive control demands, and that EM performance (both tasks) would be associated with clinical outcomes in CON. Methods: 16 CON (assessed 4–10 days post-injury [M = 6.87, SD = 2.15 days]) and 16 age-matched HC athletes were recruited. General linear mixed modeling and Pearson’s correlations were used. Results: On ANTI, CON demonstrated higher error rate [F(1,2863) = 12.650, p<.001] and shorter latency on error trials [F(1,469) = 5.976, p=.015] relative to HC. Multiple EM measures were associated with clinical outcomes: PRO duration predicted days to symptom remission (r=.44, p <.05); ANTI error rate was associated with symptom burden on the day of testing (r=.27, p <.05). Conclusion: This study demonstrates promising utility of EM measures to detect cognitive control and sensorimotor effects of concussion among female athletes and their use as a prognostic indicators of recovery.

KW - Sports-related concussion

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KW - oculomotor

KW - saccade

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Eye movement performance and clinical outcomes among female athletes post-concussion

Abstract

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Keywords

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