Eye movements as a measure of word comprehension deficits in primary progressive aphasia

Tatiana Karpouzian-Rogers*, Robert Stephen Hurley, Mustafa Seckin, Stacey Moeller, Nathan Gill, Hui Zhang, Christina Coventry, Matthew Nelson, Sandra Weintraub, Emily Rogalski, M. Marsel Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Eye movement studies can uncover subtle aspects of language processing impairment in individuals with primary progressive aphasia (PPA), who may have difficulty understanding words. This study examined eye movement patterns on a word-object matching task in response to varying levels of word-knowledge in PPA. Methods: Participants with semantic and non-semantic PPA completed an object-matching task, where a word was presented and participants then selected the corresponding pictured object from an array. Afterwards, participants defined words for trials to which they incorrectly pointed. Linear mixed-effects analyses examined fixation differences on targets and related and unrelated foils. Results: On incorrectly-pointed trials, participants demonstrated greater fixation duration on related foils, demonstrating intra-category blurring. For words that could not be defined, there was similar fixation duration on related and unrelated foils, demonstrating inter-category semantic blurring. Discussion: This study demonstrated that fixation patterns reflect varying levels of word knowledge in PPA.

Original languageEnglish (US)
Article number105165
JournalBrain and Language
Volume232
DOIs
StatePublished - Sep 2022

Keywords

  • Eye Movement
  • Primary Progressive Aphasia
  • Word Comprehension

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

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