TY - JOUR
T1 - Eye movements in amyotrophic lateral sclerosis and its mimics
T2 - A review with illustrative cases
AU - Donaghy, Colette
AU - Thurtell, Matthew J.
AU - Pioro, Erik P.
AU - Gibson, J. Mark
AU - Leigh, R. John
PY - 2011/1
Y1 - 2011/1
N2 - Abnormal eye movements are increasingly recognised in patients with amyotrophic lateral sclerosis (ALS) and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. In patients with disorders that mimic ALS, abnormal eye movements may point to the correct diagnosis. In both of these circumstances, systematic examination of eye movements and interpretation of the findings with reference to modern concepts of their neural substrate will aid diagnosis and suggest pathogenesis. Here, key points with illustrative case histories and eye movement records are highlighted.
AB - Abnormal eye movements are increasingly recognised in patients with amyotrophic lateral sclerosis (ALS) and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. In patients with disorders that mimic ALS, abnormal eye movements may point to the correct diagnosis. In both of these circumstances, systematic examination of eye movements and interpretation of the findings with reference to modern concepts of their neural substrate will aid diagnosis and suggest pathogenesis. Here, key points with illustrative case histories and eye movement records are highlighted.
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U2 - 10.1136/jnnp.2010.212407
DO - 10.1136/jnnp.2010.212407
M3 - Review article
C2 - 21097546
AN - SCOPUS:78650445324
SN - 0022-3050
VL - 82
SP - 110
EP - 116
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 1
ER -