Eye-Tracking Dysfunctions in Schizophrenic Patients and Their Relatives

Philip S. Holzman*, Leonard R. Proctor, Deborah L. Levy, Nicholas J. Yasillo, Herbert Y. Meltzer, Stephen W. Hurt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

357 Scopus citations


A simple test of smooth-pursuit eye movements disclosed a striking association between deviant eye tracking and clinically diagnosed schizophrenia. A high proportion of the schizophrenic patients' first-degree relatives who were not themselves clinically schizophrenic also showed deviant eye-tracking behavior. The relationship of poor eye tracking and schizophrenia is even stronger when specific psychological test evidence of thought disorder is used operationally to classify patients. The eye-tracking dysfunction may thus represent a genetic marker that can prove highly useful for studying the transmission of a vulnerability to schizophrenia. The findings suggest proprioceptive and interoceptive involvement in schizophrenic pathology.

Original languageEnglish (US)
Pages (from-to)143-151
Number of pages9
JournalArchives of general psychiatry
Issue number2
StatePublished - Aug 1974

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Arts and Humanities (miscellaneous)


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