Eyeblink conditioning - A behavioral model of procedural and declarative learning

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


A history of eyeblink conditioning is summarized and important terms are defined. Involvement of cerebellar circuitry mediating the procedural, delay version and involvement of forebrain regions mediating the declarative, trace version are reviewed. Recent studies in humans, including awareness, and whole brain imaging studies of humans and animals during and after learning are described. Eyeblink conditioning used to study aging, Alzheimer disease, drugs affecting cognition, and recent adaptations to mice is reviewed. Prospects for use of this well-controlled behavioral model system to study the systems, cellular and molecular mechanisms of the formation, and storage of learned associations are considered.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages29
ISBN (Electronic)9780128093245
StatePublished - Jan 1 2016


  • Association
  • Awareness
  • Cerebellum
  • Conditioned response
  • Conditioned stimulus
  • Delay
  • Eyelid
  • Hippocampus
  • Interpositus
  • Nictitating membrane
  • Pavlov
  • Prefrontal cortex
  • Pseudoconditioning
  • Trace
  • Unconditioned stimulus

ASJC Scopus subject areas

  • General Medicine


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