Facially-selective thymine-thymine photodimerization in TTT triads

Prakash P. Neelakandan, Zhengzheng Pan, Mahesh Hariharan, Frederick D. Lewis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cis-syn (2 + 2) dimers formed between the central thymine and its 3′- and 5′-neighbors. Selective formation of the 3′-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.

Original languageEnglish (US)
Pages (from-to)889-892
Number of pages4
JournalPhotochemical and Photobiological Sciences
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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