Facially-selective thymine-thymine photodimerization in TTT triads

Prakash P. Neelakandan; Zhengzheng Pan; Mahesh Hariharan; Frederick D. Lewis

doi:10.1039/c2pp25089f

Facially-selective thymine-thymine photodimerization in TTT triads

Prakash P. Neelakandan, Zhengzheng Pan, Mahesh Hariharan, Frederick D. Lewis^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cis-syn (2 + 2) dimers formed between the central thymine and its 3′- and 5′-neighbors. Selective formation of the 3′-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.

Original language	English (US)
Pages (from-to)	889-892
Number of pages	4
Journal	Photochemical and Photobiological Sciences
Volume	11
Issue number	6
DOIs	https://doi.org/10.1039/c2pp25089f
State	Published - Jun 1 2012

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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abstract = "Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cis-syn (2 + 2) dimers formed between the central thymine and its 3′- and 5′-neighbors. Selective formation of the 3′-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.",

author = "Neelakandan, {Prakash P.} and Zhengzheng Pan and Mahesh Hariharan and Lewis, {Frederick D.}",

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T1 - Facially-selective thymine-thymine photodimerization in TTT triads

AU - Neelakandan, Prakash P.

AU - Pan, Zhengzheng

AU - Hariharan, Mahesh

AU - Lewis, Frederick D.

N1 - Publisher Copyright: © The Royal Society of Chemistry and Owner Societies 2012.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cis-syn (2 + 2) dimers formed between the central thymine and its 3′- and 5′-neighbors. Selective formation of the 3′-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.

AB - Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cis-syn (2 + 2) dimers formed between the central thymine and its 3′- and 5′-neighbors. Selective formation of the 3′-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.

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U2 - 10.1039/c2pp25089f

DO - 10.1039/c2pp25089f

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JO - Photochemical and Photobiological Sciences

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ER -

Facially-selective thymine-thymine photodimerization in TTT triads

Abstract

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