Abstract
A broad range of synthetically challenging-to-access small molecule-DNA hybrids can be readily synthesized in "one pot" and in high yields by coupling multi-azide cores to alkyne-modified DNAs on a solid support using click chemistry. The multi-functional products can be obtained in pure forms and on large scales (1 μmol) in a facile fashion. In addition, the distribution of the products can be controlled by changing the concentration of the azide core in solution and the strand-loading density on the solid-supports.
Original language | English (US) |
---|---|
Pages (from-to) | 1091-1096 |
Number of pages | 6 |
Journal | Chemical Science |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2014 |
ASJC Scopus subject areas
- Chemistry(all)