Facile one-step solid-phase synthesis of multitopic organic-DNA hybrids via "click" chemistry

Ryan V. Thaner, Ibrahim Eryazici*, Omar K. Farha, Chad A. Mirkin, Sonbinh T. Nguyen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A broad range of synthetically challenging-to-access small molecule-DNA hybrids can be readily synthesized in "one pot" and in high yields by coupling multi-azide cores to alkyne-modified DNAs on a solid support using click chemistry. The multi-functional products can be obtained in pure forms and on large scales (1 μmol) in a facile fashion. In addition, the distribution of the products can be controlled by changing the concentration of the azide core in solution and the strand-loading density on the solid-supports.

Original languageEnglish (US)
Pages (from-to)1091-1096
Number of pages6
JournalChemical Science
Volume5
Issue number3
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Chemistry(all)

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