Factors associated with the successful modification of antiretroviral therapy

Paul J. Weidle*, Kenneth A. Lichtenstein, Anne C. Moorman, Jennifer C. Von Bargen, Kenneth S. Greenberg, Frank Joseph Palella Jr, Scott D. Holmberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Objectives: To assess the characteristics of medication regimen modification and the influence of a commercial genotypic resistance assay on the short-term (3-12 weeks) viral load response (≥ 0.5 log reduction) in HIV-1-infected patients extensively treated with antiretroviral therapy (ART). Methods: A nested cohort study was performed in two clinics from the HIV Outpatient Study of 96 persons with a HIV-1 viral load of 104 log copies/ml or greater taking at least two antiretroviral medications. Results: Successful modification was associated with adding at least two new medications [relative risk (RR), 1.5; 95% confidence interval (CI), 1.1-2.2], adding a drug from a previously unused class of agents (RR 2.0; CI, 1.4-2.9), the initiation of a non nucleoside reverse transcriptase inhibitor (NNRTI) (RR, 1.7; CI, 1.2-2.4), but not substituting a protease inhibitor or the use of a commercial genotypic resistance assay. Conclusion: Incorporating a drug from a previously unused class or changing at least two new medications, but, within the confines of this study, not using a commercial genotypic resistance assay, was associated with the successful modification of ART as measured by a reduction in viral load. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)491-497
Number of pages7
JournalAIDS
Volume14
Issue number5
DOIs
StatePublished - Apr 28 2000

Keywords

  • Antiretroviral therapy
  • Genotypic
  • Modification
  • Resistance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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