Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620

L. Hirschhorn, H. C. Neu

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The in vitro activity of difloxacin (A-56619) and A-56620, two new aryl-difluoroquinolones, was decreased by magnesium at 9 mM and in assay at pH 5.5 or in urine. Resistance was seen with members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and Staphylococcus aureus repeatedly exposed to subinhibitory concentrations of the compounds. The frequency of resistance was similar to that found for other new quinolones.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume30
Issue number1
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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