Factors involved in the regulation of type I collagen gene expression

Implication in fibrosis

Asish K. Ghosh*

*Corresponding author for this work

Research output: Contribution to journalShort survey

193 Citations (Scopus)

Abstract

Type I collagen, the major component of extracellular matrix in skin and other tissues, is a heterotrimer of two α1 and one α2 collagen polypeptides. The synthesis of both chains is highly regulated by different cytokines at the transcriptional level. Excessive synthesis and deposition of collagen in the dermal region causes thick and hard skin, a clinical manifestation of scleroderma. To better understand the causes of scleroderma or other tissue fibrosis, it is very important to investigate the molecular mechanisms that cause upregulation of the Type I collagen synthesis in these tissues. Several cis-acting regulatory elements and trans-acting protein factors, which are involved in basal as well as cytokine-modulated Type I collagen gene expression, have been identified and characterized. Hypertranscription of Type I collagen in scleroderma skin fibroblasts may be due to abnormal activities of different positive or negative transcription factors in response to different abnormally induced signaling pathways. In this review, I discuss the present day understanding about the involvement of different factors in the regulation of basal as well as cytokine-modulated Type I collagen gene expression and its implication in scleroderma research.

Original languageEnglish (US)
Pages (from-to)301-314
Number of pages14
JournalExperimental Biology and Medicine
Volume227
Issue number5
StatePublished - May 1 2002

Fingerprint

Collagen Type I
Gene expression
Fibrosis
Gene Expression
Skin
Tissue
Cytokines
Collagen
Trans-Activators
Fibroblasts
Extracellular Matrix
Transcription Factors
Up-Regulation
Peptides
Research
Proteins

Keywords

  • Extracellular matrix
  • IFN-γ
  • IL-1β
  • Scleroderma
  • Signal transduction
  • TGF-β
  • TNF-α
  • Transcription factors
  • Transcriptional coactivators p300/CBP
  • Type I collagen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{9e9cf3e55d9a414d84ce3778c2c2d51c,
title = "Factors involved in the regulation of type I collagen gene expression: Implication in fibrosis",
abstract = "Type I collagen, the major component of extracellular matrix in skin and other tissues, is a heterotrimer of two α1 and one α2 collagen polypeptides. The synthesis of both chains is highly regulated by different cytokines at the transcriptional level. Excessive synthesis and deposition of collagen in the dermal region causes thick and hard skin, a clinical manifestation of scleroderma. To better understand the causes of scleroderma or other tissue fibrosis, it is very important to investigate the molecular mechanisms that cause upregulation of the Type I collagen synthesis in these tissues. Several cis-acting regulatory elements and trans-acting protein factors, which are involved in basal as well as cytokine-modulated Type I collagen gene expression, have been identified and characterized. Hypertranscription of Type I collagen in scleroderma skin fibroblasts may be due to abnormal activities of different positive or negative transcription factors in response to different abnormally induced signaling pathways. In this review, I discuss the present day understanding about the involvement of different factors in the regulation of basal as well as cytokine-modulated Type I collagen gene expression and its implication in scleroderma research.",
keywords = "Extracellular matrix, IFN-γ, IL-1β, Scleroderma, Signal transduction, TGF-β, TNF-α, Transcription factors, Transcriptional coactivators p300/CBP, Type I collagen",
author = "Ghosh, {Asish K.}",
year = "2002",
month = "5",
day = "1",
language = "English (US)",
volume = "227",
pages = "301--314",
journal = "Experimental Biology and Medicine",
issn = "1535-3702",
publisher = "SAGE Publications Ltd",
number = "5",

}

Factors involved in the regulation of type I collagen gene expression : Implication in fibrosis. / Ghosh, Asish K.

In: Experimental Biology and Medicine, Vol. 227, No. 5, 01.05.2002, p. 301-314.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Factors involved in the regulation of type I collagen gene expression

T2 - Implication in fibrosis

AU - Ghosh, Asish K.

PY - 2002/5/1

Y1 - 2002/5/1

N2 - Type I collagen, the major component of extracellular matrix in skin and other tissues, is a heterotrimer of two α1 and one α2 collagen polypeptides. The synthesis of both chains is highly regulated by different cytokines at the transcriptional level. Excessive synthesis and deposition of collagen in the dermal region causes thick and hard skin, a clinical manifestation of scleroderma. To better understand the causes of scleroderma or other tissue fibrosis, it is very important to investigate the molecular mechanisms that cause upregulation of the Type I collagen synthesis in these tissues. Several cis-acting regulatory elements and trans-acting protein factors, which are involved in basal as well as cytokine-modulated Type I collagen gene expression, have been identified and characterized. Hypertranscription of Type I collagen in scleroderma skin fibroblasts may be due to abnormal activities of different positive or negative transcription factors in response to different abnormally induced signaling pathways. In this review, I discuss the present day understanding about the involvement of different factors in the regulation of basal as well as cytokine-modulated Type I collagen gene expression and its implication in scleroderma research.

AB - Type I collagen, the major component of extracellular matrix in skin and other tissues, is a heterotrimer of two α1 and one α2 collagen polypeptides. The synthesis of both chains is highly regulated by different cytokines at the transcriptional level. Excessive synthesis and deposition of collagen in the dermal region causes thick and hard skin, a clinical manifestation of scleroderma. To better understand the causes of scleroderma or other tissue fibrosis, it is very important to investigate the molecular mechanisms that cause upregulation of the Type I collagen synthesis in these tissues. Several cis-acting regulatory elements and trans-acting protein factors, which are involved in basal as well as cytokine-modulated Type I collagen gene expression, have been identified and characterized. Hypertranscription of Type I collagen in scleroderma skin fibroblasts may be due to abnormal activities of different positive or negative transcription factors in response to different abnormally induced signaling pathways. In this review, I discuss the present day understanding about the involvement of different factors in the regulation of basal as well as cytokine-modulated Type I collagen gene expression and its implication in scleroderma research.

KW - Extracellular matrix

KW - IFN-γ

KW - IL-1β

KW - Scleroderma

KW - Signal transduction

KW - TGF-β

KW - TNF-α

KW - Transcription factors

KW - Transcriptional coactivators p300/CBP

KW - Type I collagen

UR - http://www.scopus.com/inward/record.url?scp=0036586090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036586090&partnerID=8YFLogxK

M3 - Short survey

VL - 227

SP - 301

EP - 314

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 1535-3702

IS - 5

ER -