Factors predicting inhaled corticosteroid responsiveness in African American patients with asthma

Wendy Gould, Edward L. Peterson, Gloria Karungi, Amanda Zoratti, John Gaggin, Ghazwan Toma, Shiqing Yan, Albert M. Levin, James J. Yang, Karen Wells, Mingqun Wang, Robert R. Burke, Kenneth Beckman, Danijela Popadic, Susan J. Land, Rajesh Kumar, Max A. Seibold, David E. Lanfear, Esteban G. Burchard, L. Keoki Williams

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background: African American patients disproportionately experience uncontrolled asthma. Treatment with an inhaled corticosteroid (ICS) is considered first-line therapy for persistent asthma. Objective: We sought to determine the degree to which African American patients respond to ICS medication and whether the level of response is influenced by other factors, including genetic ancestry. Methods: Patients aged 12 to 56 years who received care from a large health system in southeast Michigan and who resided in Detroit were recruited to participate if they had a diagnosis of asthma. Patients were treated with 6 weeks of inhaled beclomethasone dipropionate, and pulmonary function was remeasured after treatment. Ancestry was determined by genotyping ancestry-informative markers. The main outcome measure was ICS responsiveness defined as the change in prebronchodilator FEV1 over the 6-week course of treatment. Results: Among 147 participating African American patients with asthma, average improvement in FEV1 after 6 weeks of ICS treatment was 11.6%. The mean proportion of African ancestry in this group was 78.4%. The degree of baseline bronchodilator reversibility was the only factor consistently associated with ICS responsiveness, as measured by both an improvement in FEV1 and patient-reported asthma control (P = .001 and P = .021, respectively). The proportion of African ancestry was not significantly associated with ICS responsiveness. Conclusions: Although baseline pulmonary function parameters appear to be associated with the likelihood to respond to ICS treatment, the proportion of genetic African ancestry does not. This study suggests that genetic ancestry might not contribute to differences in ICS controller response among African American patients with asthma.

Original languageEnglish (US)
Pages (from-to)1131-1138
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume126
Issue number6
DOIs
StatePublished - Dec 2010

Keywords

  • Inhaled corticosteroids
  • ancestry
  • asthma
  • continental population groups
  • race-ethnicity
  • urban health

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Gould, W., Peterson, E. L., Karungi, G., Zoratti, A., Gaggin, J., Toma, G., Yan, S., Levin, A. M., Yang, J. J., Wells, K., Wang, M., Burke, R. R., Beckman, K., Popadic, D., Land, S. J., Kumar, R., Seibold, M. A., Lanfear, D. E., Burchard, E. G., & Williams, L. K. (2010). Factors predicting inhaled corticosteroid responsiveness in African American patients with asthma. Journal of Allergy and Clinical Immunology, 126(6), 1131-1138. https://doi.org/10.1016/j.jaci.2010.08.002