Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat

L. Christine Turtzo, Matthew D. Budde, Dana D. Dean, Eric M. Gold, Bobbi K. Lewis, Lindsay Janes, Jacob Lescher, Tiziana Coppola, Angela Yarnell, Neil E. Grunberg, Joseph A. Frank

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide a regenerative medicine option for the treatment of traumatic brain injury. The present study investigates the efficacy of multiple intravenous or intracardiac administrations of rat mesenchymal stromal cells or human mesenchymal stromal cells in female rats after controlled cortical impact by in vivo MRI, neurobehavior, and histopathology evaluation. Neither intravenous nor intracardiac administration of mesenchymal stromal cells derived from either rats or humans improved MRI measures of lesion volume or neurobehavioral outcome compared to saline treatment. Few mesenchymal stromal cells (<0.0005%of injected dose) were found within 3 days of last dosage at the site of injury after either delivery route, with no mesenchymal stromal cells being detectable in brain at 30 or 56 days post-injury. These findings suggest that non-autologous mesenchymal stromal cells therapy via intravenous or intracardiac administration is not a promising treatment after focal contusion traumatic brain injury in this female rodent model.

Original languageEnglish (US)
Article numbere0126551
JournalPloS one
Volume10
Issue number5
DOIs
StatePublished - May 6 2015

ASJC Scopus subject areas

  • General

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