Familial acute myeloid leukaemia: Four male members of a single family over three consecutive generations exhibiting anticipation

C. De Lord*, R. Powles, J. Mehta, K. Wilson, J. Treleaven, S. Meller, D. Catovsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A kindred with familial acute myeloid leukaemia (AML) is described displaying the concept of anticipation which refers to increased disease severity and/or earlier age at onset with succeeding generations. The affected individual in the first generation was the father (aged 34 years at diagnosis) of two affected members of a single sibship (aged 24 and 25 years). The fourth patient is the son (aged 4 years) of one of these brothers in the second generation. The AMI, was of different subtypes and a karyotypic abnormality (del[6q]) was detected in one of three patients. The first- generation patient died during chemotherapy; the remaining three patients are in complete remission after chemotherapy and autologous bone marrow transplantation.

Original languageEnglish (US)
Pages (from-to)557-560
Number of pages4
JournalBritish Journal of Haematology
Volume100
Issue number3
DOIs
StatePublished - 1998

Keywords

  • Anticipation
  • Familial acute myeloid leukaemia
  • Trinucleotide repeats

ASJC Scopus subject areas

  • Hematology

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