Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry

Sampath Prahalad; Courtney E. McCracken; Lori A. Ponder; Sheila T. Angeles-Han; Kelly A. Rouster Stevens; Larry B. Vogler; Carl D. Langefeld; Susan D. Thompson; L. Abramson; E. Anderson; M. Andrew; N. Battle; M. Becker; H. Benham; T. Beukelman; J. Birmingham; P. Blier; A. Brown; H. Brunner; A. Cabrera; D. Canter; D. Carlton; B. Caruso; L. Ceracchio; E. Chalom; J. Chang; P. Charpentier; K. Clark; J. Dean; F. Dedeoglu; B. Feldman; P. Ferguson; M. Fox; K. Francis; M. Gervasini; D. Goldsmith; G. Gorton; B. Gottlieb; T. Graham; T. Griffin; H. Grosbein; S. Guppy; H. Haftel; D. Helfrich; G. Higgins; A. Hillard; J. R. Hollister; J. Hsu; A. Hudgins; M. Klein-Gitelman; and for The CARRA Registry Investigators

doi:10.1186/s12969-016-0075-7

Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry

Sampath Prahalad, Courtney E. McCracken, Lori A. Ponder, Sheila T. Angeles-Han, Kelly A. Rouster Stevens, Larry B. Vogler, Carl D. Langefeld, Susan D. Thompson, L. Abramson, E. Anderson, M. Andrew, N. Battle, M. Becker, H. Benham, T. Beukelman, J. Birmingham, P. Blier, A. Brown, H. Brunner, A. CabreraD. Canter, D. Carlton, B. Caruso, L. Ceracchio, E. Chalom, J. Chang, P. Charpentier, K. Clark, J. Dean, F. Dedeoglu, B. Feldman, P. Ferguson, M. Fox, K. Francis, M. Gervasini, D. Goldsmith, G. Gorton, B. Gottlieb, T. Graham, T. Griffin, H. Grosbein, S. Guppy, H. Haftel, D. Helfrich, G. Higgins, A. Hillard, J. R. Hollister, J. Hsu, A. Hudgins, M. Klein-Gitelman, and for The CARRA Registry Investigators

Pediatrics

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17 Scopus citations

Abstract

Background: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Methods: Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. Results: There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5%) was less compared to subjects with JIA (31.8%, p < 0.001) or SLE (31.9%; p < 0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13%) compared to cSLE (9.2%, p = 0.007) or JDM (4.3%, p <0.001). Significantly greater proportion of cSLE cases had FDR with SLE (11.1% vs. 1.7% for JIA and 1.1% for JDM p < 0.001) or type-I diabetes (7.4% for cSLE vs. 3.1% for JIA and 3.0% for JDM p < 0.001). Conclusion: Higher proportions of subjects with JIA and cSLE have FDR with autoimmunity compared to those of JDM. Relatives of cSLE cases had an increased prevalence of SLE, and relatives of JIA cases were enriched for inflammatory arthropathies demonstrating distinct patterns of familial autoimmunity among these phenotypes.

Original language	English (US)
Article number	14
Journal	Pediatric Rheumatology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s12969-016-0075-7
State	Published - Mar 10 2016

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Rheumatology
Immunology and Allergy

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12969-016-0075-7

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Prahalad, S., McCracken, C. E., Ponder, L. A., Angeles-Han, S. T., Rouster Stevens, K. A., Vogler, L. B., Langefeld, C. D., Thompson, S. D., Abramson, L., Anderson, E., Andrew, M., Battle, N., Becker, M., Benham, H., Beukelman, T., Birmingham, J., Blier, P., Brown, A., Brunner, H., ... and for The CARRA Registry Investigators (2016). Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry. Pediatric Rheumatology, 14(1), [14]. https://doi.org/10.1186/s12969-016-0075-7

@article{d33e2735166c45b787dc4c3e9e7ace29,

title = "Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry",

abstract = "Background: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Methods: Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. Results: There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5%) was less compared to subjects with JIA (31.8%, p < 0.001) or SLE (31.9%; p < 0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13%) compared to cSLE (9.2%, p = 0.007) or JDM (4.3%, p <0.001). Significantly greater proportion of cSLE cases had FDR with SLE (11.1% vs. 1.7% for JIA and 1.1% for JDM p < 0.001) or type-I diabetes (7.4% for cSLE vs. 3.1% for JIA and 3.0% for JDM p < 0.001). Conclusion: Higher proportions of subjects with JIA and cSLE have FDR with autoimmunity compared to those of JDM. Relatives of cSLE cases had an increased prevalence of SLE, and relatives of JIA cases were enriched for inflammatory arthropathies demonstrating distinct patterns of familial autoimmunity among these phenotypes.",

author = "Sampath Prahalad and McCracken, {Courtney E.} and Ponder, {Lori A.} and Angeles-Han, {Sheila T.} and {Rouster Stevens}, {Kelly A.} and Vogler, {Larry B.} and Langefeld, {Carl D.} and Thompson, {Susan D.} and L. Abramson and E. Anderson and M. Andrew and N. Battle and M. Becker and H. Benham and T. Beukelman and J. Birmingham and P. Blier and A. Brown and H. Brunner and A. Cabrera and D. Canter and D. Carlton and B. Caruso and L. Ceracchio and E. Chalom and J. Chang and P. Charpentier and K. Clark and J. Dean and F. Dedeoglu and B. Feldman and P. Ferguson and M. Fox and K. Francis and M. Gervasini and D. Goldsmith and G. Gorton and B. Gottlieb and T. Graham and T. Griffin and H. Grosbein and S. Guppy and H. Haftel and D. Helfrich and G. Higgins and A. Hillard and Hollister, {J. R.} and J. Hsu and A. Hudgins and M. Klein-Gitelman and {and for The CARRA Registry Investigators}",

note = "Funding Information: Dr. Prahalad is supported by grants from The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (01-AR060893), Arthritis Foundation and The Marcus Foundation Inc. CARRA Registry is supported by grants from NIAMS (RC2-AR058934), Friends of CARRA, the Arthritis Foundation, and the Duke Clinical Research Institute. Dr. Thompson is supported by grants from NIAMS (P01-AR048929 and P30-AR0470363), The Arthritis Foundation and Cincinnati Children{\textquoteright}s Hospital Research Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIAMS or the National Institutes of Health. The authors would like to thank all participants and hospital sites that recruited patients for the CARRA Registry. The authors thank the following CARRA Registry site principal investigators and research coordinators: L. Abramson, E. Anderson, M. Andrew, N. Battle, M. Becker, H. Benham, T. Beukelman, J. Birmingham, P. Blier, A. Brown, H. Brunner, A. Cabrera, D. Canter, D. Carlton, B. Caruso, L. Ceracchio, E. Chalom, J. Chang, P. Charpentier, K. Clark, J. Dean, F. Dedeoglu, B. Feldman, P. Ferguson, M. Fox, K. Francis, M. Gervasini, D. Goldsmith, G. Gorton, B. Gottlieb, T. Graham, T. Griffin, H. Grosbein, S. Guppy, H. Haftel, D. Helfrich, G. Higgins, A. Hillard, J.R. Hollister, J. Hsu, A. Hudgins, C. Hung, A. Huttenlocher, N. Ilowite, A. Imlay, L. Imundo, C.J. Inman, J. Jaqith, R. Jerath, L. Jung, P. Kahn, A. Kapedani, D. Kingsbury, K. Klein, M. Klein-Gitelman, A. Kunkel, S. Lapidus, S. Layburn, T. Lehman, C. Lindsley, M. Macgregor-Hannah, M. Malloy, C. Mawhorter, D. McCurdy, K. Mims, N. Moorthy, D. Morus, E. Muscal, M. Natter, J. Olson, K. O{\textquoteright}Neil, K. Onel, M. Orlando, J. Palmquist, M. Phillips, L. Ponder, S. Prahalad, M. Punaro, D. Puplava, S. Quinn, A. Quintero, C. Rabinovich, A. Reed, C. Reed, S. Ringold, M. Riordan, S. Roberson, A. Robinson, J. Rossette, D. Rothman, D. Russo, N. Ruth, K. Schikler, A. Sestak, B. Shaham, Y. Sherman, M. Simmons, N. Singer, S. Spalding, H. Stapp, R. Syed, E. Thomas, K. Torok, D. Trejo, J. Tress, W. Upton, R. Vehe, E. von Scheven, L. Walters, J. Weiss, P. Weiss, N. Welnick, A. White, J. Woo, J. Wootton, A. Yalcindag, C. Zapp, L. Zemel, and A. Zhu. Publisher Copyright: {\textcopyright} 2016 Prahalad et al.",

year = "2016",

month = mar,

day = "10",

doi = "10.1186/s12969-016-0075-7",

language = "English (US)",

volume = "14",

journal = "Pediatric Rheumatology",

issn = "1546-0096",

publisher = "BioMed Central",

number = "1",

}

Prahalad, S, McCracken, CE, Ponder, LA, Angeles-Han, ST, Rouster Stevens, KA, Vogler, LB, Langefeld, CD, Thompson, SD, Abramson, L, Anderson, E, Andrew, M, Battle, N, Becker, M, Benham, H, Beukelman, T, Birmingham, J, Blier, P, Brown, A, Brunner, H, Cabrera, A, Canter, D, Carlton, D, Caruso, B, Ceracchio, L, Chalom, E, Chang, J, Charpentier, P, Clark, K, Dean, J, Dedeoglu, F, Feldman, B, Ferguson, P, Fox, M, Francis, K, Gervasini, M, Goldsmith, D, Gorton, G, Gottlieb, B, Graham, T, Griffin, T, Grosbein, H, Guppy, S, Haftel, H, Helfrich, D, Higgins, G, Hillard, A, Hollister, JR, Hsu, J, Hudgins, A, Klein-Gitelman, M & and for The CARRA Registry Investigators 2016, 'Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry', Pediatric Rheumatology, vol. 14, no. 1, 14. https://doi.org/10.1186/s12969-016-0075-7

TY - JOUR

T1 - Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry

AU - Prahalad, Sampath

AU - McCracken, Courtney E.

AU - Ponder, Lori A.

AU - Angeles-Han, Sheila T.

AU - Rouster Stevens, Kelly A.

AU - Vogler, Larry B.

AU - Langefeld, Carl D.

AU - Thompson, Susan D.

AU - Abramson, L.

AU - Anderson, E.

AU - Andrew, M.

AU - Battle, N.

AU - Becker, M.

AU - Benham, H.

AU - Beukelman, T.

AU - Birmingham, J.

AU - Blier, P.

AU - Brown, A.

AU - Brunner, H.

AU - Cabrera, A.

AU - Canter, D.

AU - Carlton, D.

AU - Caruso, B.

AU - Ceracchio, L.

AU - Chalom, E.

AU - Chang, J.

AU - Charpentier, P.

AU - Clark, K.

AU - Dean, J.

AU - Dedeoglu, F.

AU - Feldman, B.

AU - Ferguson, P.

AU - Fox, M.

AU - Francis, K.

AU - Gervasini, M.

AU - Goldsmith, D.

AU - Gorton, G.

AU - Gottlieb, B.

AU - Graham, T.

AU - Griffin, T.

AU - Grosbein, H.

AU - Guppy, S.

AU - Haftel, H.

AU - Helfrich, D.

AU - Higgins, G.

AU - Hillard, A.

AU - Hollister, J. R.

AU - Hsu, J.

AU - Hudgins, A.

AU - Klein-Gitelman, M.

AU - and for The CARRA Registry Investigators

N1 - Funding Information: Dr. Prahalad is supported by grants from The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (01-AR060893), Arthritis Foundation and The Marcus Foundation Inc. CARRA Registry is supported by grants from NIAMS (RC2-AR058934), Friends of CARRA, the Arthritis Foundation, and the Duke Clinical Research Institute. Dr. Thompson is supported by grants from NIAMS (P01-AR048929 and P30-AR0470363), The Arthritis Foundation and Cincinnati Children’s Hospital Research Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIAMS or the National Institutes of Health. The authors would like to thank all participants and hospital sites that recruited patients for the CARRA Registry. The authors thank the following CARRA Registry site principal investigators and research coordinators: L. Abramson, E. Anderson, M. Andrew, N. Battle, M. Becker, H. Benham, T. Beukelman, J. Birmingham, P. Blier, A. Brown, H. Brunner, A. Cabrera, D. Canter, D. Carlton, B. Caruso, L. Ceracchio, E. Chalom, J. Chang, P. Charpentier, K. Clark, J. Dean, F. Dedeoglu, B. Feldman, P. Ferguson, M. Fox, K. Francis, M. Gervasini, D. Goldsmith, G. Gorton, B. Gottlieb, T. Graham, T. Griffin, H. Grosbein, S. Guppy, H. Haftel, D. Helfrich, G. Higgins, A. Hillard, J.R. Hollister, J. Hsu, A. Hudgins, C. Hung, A. Huttenlocher, N. Ilowite, A. Imlay, L. Imundo, C.J. Inman, J. Jaqith, R. Jerath, L. Jung, P. Kahn, A. Kapedani, D. Kingsbury, K. Klein, M. Klein-Gitelman, A. Kunkel, S. Lapidus, S. Layburn, T. Lehman, C. Lindsley, M. Macgregor-Hannah, M. Malloy, C. Mawhorter, D. McCurdy, K. Mims, N. Moorthy, D. Morus, E. Muscal, M. Natter, J. Olson, K. O’Neil, K. Onel, M. Orlando, J. Palmquist, M. Phillips, L. Ponder, S. Prahalad, M. Punaro, D. Puplava, S. Quinn, A. Quintero, C. Rabinovich, A. Reed, C. Reed, S. Ringold, M. Riordan, S. Roberson, A. Robinson, J. Rossette, D. Rothman, D. Russo, N. Ruth, K. Schikler, A. Sestak, B. Shaham, Y. Sherman, M. Simmons, N. Singer, S. Spalding, H. Stapp, R. Syed, E. Thomas, K. Torok, D. Trejo, J. Tress, W. Upton, R. Vehe, E. von Scheven, L. Walters, J. Weiss, P. Weiss, N. Welnick, A. White, J. Woo, J. Wootton, A. Yalcindag, C. Zapp, L. Zemel, and A. Zhu. Publisher Copyright: © 2016 Prahalad et al.

PY - 2016/3/10

Y1 - 2016/3/10

N2 - Background: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Methods: Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. Results: There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5%) was less compared to subjects with JIA (31.8%, p < 0.001) or SLE (31.9%; p < 0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13%) compared to cSLE (9.2%, p = 0.007) or JDM (4.3%, p <0.001). Significantly greater proportion of cSLE cases had FDR with SLE (11.1% vs. 1.7% for JIA and 1.1% for JDM p < 0.001) or type-I diabetes (7.4% for cSLE vs. 3.1% for JIA and 3.0% for JDM p < 0.001). Conclusion: Higher proportions of subjects with JIA and cSLE have FDR with autoimmunity compared to those of JDM. Relatives of cSLE cases had an increased prevalence of SLE, and relatives of JIA cases were enriched for inflammatory arthropathies demonstrating distinct patterns of familial autoimmunity among these phenotypes.

AB - Background: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease. Methods: Children with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made. Results: There were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5%) was less compared to subjects with JIA (31.8%, p < 0.001) or SLE (31.9%; p < 0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13%) compared to cSLE (9.2%, p = 0.007) or JDM (4.3%, p <0.001). Significantly greater proportion of cSLE cases had FDR with SLE (11.1% vs. 1.7% for JIA and 1.1% for JDM p < 0.001) or type-I diabetes (7.4% for cSLE vs. 3.1% for JIA and 3.0% for JDM p < 0.001). Conclusion: Higher proportions of subjects with JIA and cSLE have FDR with autoimmunity compared to those of JDM. Relatives of cSLE cases had an increased prevalence of SLE, and relatives of JIA cases were enriched for inflammatory arthropathies demonstrating distinct patterns of familial autoimmunity among these phenotypes.

UR - http://www.scopus.com/inward/record.url?scp=84960427338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960427338&partnerID=8YFLogxK

U2 - 10.1186/s12969-016-0075-7

DO - 10.1186/s12969-016-0075-7

M3 - Article

C2 - 26965173

AN - SCOPUS:84960427338

SN - 1546-0096

VL - 14

JO - Pediatric Rheumatology

JF - Pediatric Rheumatology

IS - 1

M1 - 14

ER -

Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry

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