Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene.

G. K. Klintworth; J. R. Sommer; G. Obrian; L. Han; M. N. Ahmed; M. B. Qumsiyeh; P. Y. Lin; S. Basti; M. K. Reddy; A. Kanai; Y. Hotta; J. Sugar; G. Kumaramanickavel; F. Munier; D. F. Schorderet; L. El Matri; F. Iwata; M. Kaiser-Kupfer; M. Nagata; K. Nakayasu; J. F. Hejtmancik; C. T. Teng

Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene.

G. K. Klintworth^*, J. R. Sommer, G. Obrian, L. Han, M. N. Ahmed, M. B. Qumsiyeh, P. Y. Lin, S. Basti, M. K. Reddy, A. Kanai, Y. Hotta, J. Sugar, G. Kumaramanickavel, F. Munier, D. F. Schorderet, L. El Matri, F. Iwata, M. Kaiser-Kupfer, M. Nagata, K. NakayasuJ. F. Hejtmancik, C. T. Teng

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

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Abstract

PURPOSE: Because corneal tissue with familial subepithelial corneal amyloidosis (FSCA; gelatinous drop-like dystrophy of the cornea) contains lactoferrin the possibility that the FSCA gene was the human lactoferrin (hLF) gene was investigated. Due to contradictory published information we also mapped the hLF gene. METHODS: We mapped the hLF gene using a genomic clone of the entire hLF gene as a probe by fluorescence in situ hybridization (FISH). Utilizing PCR primers that are specific to the hLF gene, we also mapped the hLF via radiation somatic cell hybrid analysis. Linkage of the FSCA gene to the hLF gene was evaluated by genetic linkage analysis using polymorphic markers within and in the vicinity of the hLF gene. RESULTS: The hLF gene mapped to the short arm of chromosome 3 at 3p21. Linkage analysis using polymorphic markers for hLF and haplotype analysis of the 3p21 loci indicates that the FSCA gene is not linked to the 3p21 locus. CONCLUSIONS: The gene for FSCA is not the hLF gene in these families.

Original language	English (US)
Pages (from-to)	31
Number of pages	1
Journal	Molecular vision
Volume	4
State	Published - Dec 31 1998

ASJC Scopus subject areas

Ophthalmology

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Klintworth, G. K., Sommer, J. R., Obrian, G., Han, L., Ahmed, M. N., Qumsiyeh, M. B., Lin, P. Y., Basti, S., Reddy, M. K., Kanai, A., Hotta, Y., Sugar, J., Kumaramanickavel, G., Munier, F., Schorderet, D. F., El Matri, L., Iwata, F., Kaiser-Kupfer, M., Nagata, M., ... Teng, C. T. (1998). Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene. Molecular vision, 4, 31.

@article{f7d35c783d254cd0b426f335ae36e5fe,

title = "Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene.",

abstract = "PURPOSE: Because corneal tissue with familial subepithelial corneal amyloidosis (FSCA; gelatinous drop-like dystrophy of the cornea) contains lactoferrin the possibility that the FSCA gene was the human lactoferrin (hLF) gene was investigated. Due to contradictory published information we also mapped the hLF gene. METHODS: We mapped the hLF gene using a genomic clone of the entire hLF gene as a probe by fluorescence in situ hybridization (FISH). Utilizing PCR primers that are specific to the hLF gene, we also mapped the hLF via radiation somatic cell hybrid analysis. Linkage of the FSCA gene to the hLF gene was evaluated by genetic linkage analysis using polymorphic markers within and in the vicinity of the hLF gene. RESULTS: The hLF gene mapped to the short arm of chromosome 3 at 3p21. Linkage analysis using polymorphic markers for hLF and haplotype analysis of the 3p21 loci indicates that the FSCA gene is not linked to the 3p21 locus. CONCLUSIONS: The gene for FSCA is not the hLF gene in these families.",

author = "Klintworth, {G. K.} and Sommer, {J. R.} and G. Obrian and L. Han and Ahmed, {M. N.} and Qumsiyeh, {M. B.} and Lin, {P. Y.} and S. Basti and Reddy, {M. K.} and A. Kanai and Y. Hotta and J. Sugar and G. Kumaramanickavel and F. Munier and Schorderet, {D. F.} and {El Matri}, L. and F. Iwata and M. Kaiser-Kupfer and M. Nagata and K. Nakayasu and Hejtmancik, {J. F.} and Teng, {C. T.}",

year = "1998",

month = dec,

day = "31",

language = "English (US)",

volume = "4",

pages = "31",

journal = "Molecular Vision",

issn = "1090-0535",

publisher = "Molecular Vision",

}

Klintworth, GK, Sommer, JR, Obrian, G, Han, L, Ahmed, MN, Qumsiyeh, MB, Lin, PY, Basti, S, Reddy, MK, Kanai, A, Hotta, Y, Sugar, J, Kumaramanickavel, G, Munier, F, Schorderet, DF, El Matri, L, Iwata, F, Kaiser-Kupfer, M, Nagata, M, Nakayasu, K, Hejtmancik, JF & Teng, CT 1998, 'Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene.', Molecular vision, vol. 4, pp. 31.

TY - JOUR

T1 - Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy)

T2 - exclusion of linkage to lactoferrin gene.

AU - Klintworth, G. K.

AU - Sommer, J. R.

AU - Obrian, G.

AU - Han, L.

AU - Ahmed, M. N.

AU - Qumsiyeh, M. B.

AU - Lin, P. Y.

AU - Basti, S.

AU - Reddy, M. K.

AU - Kanai, A.

AU - Hotta, Y.

AU - Sugar, J.

AU - Kumaramanickavel, G.

AU - Munier, F.

AU - Schorderet, D. F.

AU - El Matri, L.

AU - Iwata, F.

AU - Kaiser-Kupfer, M.

AU - Nagata, M.

AU - Nakayasu, K.

AU - Hejtmancik, J. F.

AU - Teng, C. T.

PY - 1998/12/31

Y1 - 1998/12/31

N2 - PURPOSE: Because corneal tissue with familial subepithelial corneal amyloidosis (FSCA; gelatinous drop-like dystrophy of the cornea) contains lactoferrin the possibility that the FSCA gene was the human lactoferrin (hLF) gene was investigated. Due to contradictory published information we also mapped the hLF gene. METHODS: We mapped the hLF gene using a genomic clone of the entire hLF gene as a probe by fluorescence in situ hybridization (FISH). Utilizing PCR primers that are specific to the hLF gene, we also mapped the hLF via radiation somatic cell hybrid analysis. Linkage of the FSCA gene to the hLF gene was evaluated by genetic linkage analysis using polymorphic markers within and in the vicinity of the hLF gene. RESULTS: The hLF gene mapped to the short arm of chromosome 3 at 3p21. Linkage analysis using polymorphic markers for hLF and haplotype analysis of the 3p21 loci indicates that the FSCA gene is not linked to the 3p21 locus. CONCLUSIONS: The gene for FSCA is not the hLF gene in these families.

AB - PURPOSE: Because corneal tissue with familial subepithelial corneal amyloidosis (FSCA; gelatinous drop-like dystrophy of the cornea) contains lactoferrin the possibility that the FSCA gene was the human lactoferrin (hLF) gene was investigated. Due to contradictory published information we also mapped the hLF gene. METHODS: We mapped the hLF gene using a genomic clone of the entire hLF gene as a probe by fluorescence in situ hybridization (FISH). Utilizing PCR primers that are specific to the hLF gene, we also mapped the hLF via radiation somatic cell hybrid analysis. Linkage of the FSCA gene to the hLF gene was evaluated by genetic linkage analysis using polymorphic markers within and in the vicinity of the hLF gene. RESULTS: The hLF gene mapped to the short arm of chromosome 3 at 3p21. Linkage analysis using polymorphic markers for hLF and haplotype analysis of the 3p21 loci indicates that the FSCA gene is not linked to the 3p21 locus. CONCLUSIONS: The gene for FSCA is not the hLF gene in these families.

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M3 - Article

C2 - 9873069

AN - SCOPUS:17944397416

SN - 1090-0535

VL - 4

SP - 31

JO - Molecular Vision

JF - Molecular Vision

ER -

Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene.

Abstract

ASJC Scopus subject areas

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