Family history of hypertension and red cell cation transport in high school students

Richard Cooper*, Kenneth Millert, Maurizio Trevisan, Christopher Sempos, Emmanuel Larbi, Hirotsugu Ueshima, Daniel Le Grady, David Ostrow, Jeremiah Stamler, Anda Spalvins, Mitzy Canessa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


High school students who had at least one parent with hypertension (n = 22) were compared to schoolmates of the same age with a negative family history of hypertension in the parents (n =21). We investigated in both groups the maximal rate of the ouabain-sensitive Na pump and the Na-K cotransport in nystatin-loaded cells and the LirNa0 countertransport in lithium-loaded cells. The two groups were significantly different only in the sum of net Na transport mediated by the Na-K pump and Na-K cotransport. The mean diastolic blood pressure in the positive family history group was significantly higher. With control for blood pressure the difference in the maximal rate of Na transport was no longer significant; it remains uncertain if control for blood pressure represents ‘over-adjustment’. The finding of a higher maximal rate of Na transport in these adolescents who are at increased risk of future hypertension, yet currently well within the normal range, suggests that abnormal sodium metabolism may be a useful marker and appears early in the pathogenesis of this disease.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalJournal of hypertension
Issue number2
StatePublished - Aug 1983


  • Cation transport
  • Family history
  • Hypertension
  • Sodium

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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