Fast gradient echo MR imaging of the liver enhanced with superparamagnetic iron oxide

Mark Fishbein*, Fred Long, Mark Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The purpose of this study was to develop a breath-hold technique for hepatic imaging using SPIO-enhanced gradient echo. Pre- and post-SPIO driven equilibrium fast gradient echo scans were performed on five healthy subjects. Scan parameters were established to emphasize large pre-/post-signal differences while maintaining a scan time conducive to breath-hold. Hepatic post-SPIO signal reduction was at least fifty percent with diagnostic image quality in all subjects. SPIO-enhanced gradient echo provides slightly less hepatic signal reduction to spin echo techniques but can be performed within a single breath-hold. This technique may be advantageous over SE in assessing hepatic pathology in subjects unable to lay motionless for prolonged intervals, such as children.

Original languageEnglish (US)
Pages (from-to)651-655
Number of pages5
JournalMagnetic Resonance Imaging
Issue number6
StatePublished - 1997


  • Fast gradient echo
  • Liver
  • Spin echo
  • Superparamagnetic iron oxide

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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