Abstract
Objectives: Genetic variation in the fat mass-and obesity-associated gene (FTO) has been associated with obesity in the general population. In this study we have investigated these variants for association with antipsychotic-induced weight gain (AIWG). Methods: A total of 218 patients with chronic schizophrenia or schizoaffective disorder treated mostly with clozapine or olanzapine for up to 14 weeks were included in the study. We analyzed 4 polymorphisms in intron 1 of the FTO gene (rs1421085, rs8050136, rs9939609, rs9930506) for association with AIWG using ANCOVA. Results: No statistically significant associations were observed between the single nucleotide polymorphisms and AIWG. However, patients homozygous for the A-allele of rs9939609 gained numerically higher weight than the other genotypic groups (AA: 5.26 ± 6.7%; TA: 4.66 ± 5.6%; TT: 4.21 ± 5.3%). Conclusion: Our current observations suggest that the FTO gene variants investigated may not play a major role in AIWG.
Original language | English (US) |
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Pages (from-to) | 59-63 |
Number of pages | 5 |
Journal | Neuropsychobiology |
Volume | 69 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2014 |
Keywords
- Antipsychotics
- Association
- FTO
- Pharmacogenetics
- Weight gain
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Psychiatry and Mental health
- Biological Psychiatry
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Supplementary Material for: Fat Mass- and Obesity-Associated (FTO) Gene and Antipsychotic-Induced Weight Gain: An Association Study
Shing, E. C. (Creator), Tiwari, A. K. (Creator), Brandl, E. J. (Creator), Zai, C. C. (Creator), Lieberman, J. A. (Creator), Meltzer, H. Y. (Creator), Kennedy, J. L. (Creator), Müller, D. J. (Creator), Tiwari, A. K. (Creator), Zai, C. C. (Creator) & Meltzer, H. Y. (Creator), Karger Publishers, 2014
DOI: 10.6084/m9.figshare.5125795.v1, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Fat_Mass-_and_Obesity-Associated_FTO_Gene_and_Antipsychotic-Induced_Weight_Gain_An_Association_Study/5125795/1
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