Fat mass-and obesity-associated (FTO) gene and antipsychotic-induced weight gain: An association study

Emily C. Shing, Arun K. Tiwari, Eva J. Brandl, Clement C. Zai, Jeffrey A. Lieberman, Herbert Y. Meltzer, James L. Kennedy, Daniel J. Müller

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objectives: Genetic variation in the fat mass-and obesity-associated gene (FTO) has been associated with obesity in the general population. In this study we have investigated these variants for association with antipsychotic-induced weight gain (AIWG). Methods: A total of 218 patients with chronic schizophrenia or schizoaffective disorder treated mostly with clozapine or olanzapine for up to 14 weeks were included in the study. We analyzed 4 polymorphisms in intron 1 of the FTO gene (rs1421085, rs8050136, rs9939609, rs9930506) for association with AIWG using ANCOVA. Results: No statistically significant associations were observed between the single nucleotide polymorphisms and AIWG. However, patients homozygous for the A-allele of rs9939609 gained numerically higher weight than the other genotypic groups (AA: 5.26 ± 6.7%; TA: 4.66 ± 5.6%; TT: 4.21 ± 5.3%). Conclusion: Our current observations suggest that the FTO gene variants investigated may not play a major role in AIWG.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalNeuropsychobiology
Volume69
Issue number1
DOIs
StatePublished - Feb 2014

Keywords

  • Antipsychotics
  • Association
  • FTO
  • Pharmacogenetics
  • Weight gain

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Shing, E. C., Tiwari, A. K., Brandl, E. J., Zai, C. C., Lieberman, J. A., Meltzer, H. Y., Kennedy, J. L., & Müller, D. J. (2014). Fat mass-and obesity-associated (FTO) gene and antipsychotic-induced weight gain: An association study. Neuropsychobiology, 69(1), 59-63. https://doi.org/10.1159/000356231