Fat mass modifies the association of fat-free mass with symptom-limited treadmill duration in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Na Zhu, David R. Jacobs*, Stephen Sidney, Barbara Sternfeld, Mercedes Carnethon, Cora E. Lewis, Christina M. Shay, Akshay Sood, Claude Bouchard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: The assessment of fat mass and fat-free mass in relation to the symptom-limited maximal exercise duration (Max dur) of a treadmill test allows for insight into the association of body composition with treadmill performance potential. Objective: We investigated the complex associations between fat mass and fat-free mass and Max dur in a population setting. Design: The Max dur of a graded exercise treadmill test and body composition by dual-energy X-ray absorptiometry were estimated in 2413 black and white men and women aged 38-50 y from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. Results: The mean Max dur was ≈7.5 s shorter per kilogram of fat mass in both men and women and independent of fat-free mass, height, race, television watching, physical activity, systolic blood pressure, lung function, and education. Fat mass modified the association of fat-free mass with the Max dur (2-way interaction P < 0.001), and the interaction was stronger in women than in men. In men in the lowest fat-mass quartile, the Max dur was 1.3 s longer per kilogram of fat-free mass and was 0.5 s shorter per kilogram of fat-free mass in the highest fat-mass quartile. In contrast, in women with the least fat mass, the Max dur was 2.7 s longer per kilogram of fat-free mass and was 2.8 s shorter per kilogram of fat-free mass in the highest fat-mass quartile. Conclusions: The Max dur was negatively related to fat mass. Fat-free mass in obese people contributed little to the treadmill performance potential as assessed by the Max dur, although the contribution of fat-free mass was positive in thinner people.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume94
Issue number2
DOIs
StatePublished - Aug 1 2011

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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