TY - JOUR
T1 - Fatal and near-fatal anaphylaxis
T2 - Factors that can worsen or contribute to fatal outcomes
AU - Greenberger, Paul A.
N1 - Funding Information:
Supported by the Ernest S. Bazley Trust to Northwestern Memorial Hospital and Northwestern University.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Anaphylaxis implies a risk of death even in patients whose prior episodes have been considered mild and managed easily. Anaphylaxis occurs in all age groups, from infants to the elderly, but most deaths occur in adults. Factors or circumstances associated with near-fatal or fatal anaphylaxis are reviewed from the following 10 perspectives: accidents and mishaps, adulterated products, age, allergens, atopy, comorbidities, Munchausen syndrome or contrived anaphylaxis, patient factors, route of administration, and treatment-related issues. There are no absolute contraindications to self-injectable epinephrine, and epinephrine can be administered for anaphylaxis to elderly patients or to those patients receiving beta-adrenergic blockers.
AB - Anaphylaxis implies a risk of death even in patients whose prior episodes have been considered mild and managed easily. Anaphylaxis occurs in all age groups, from infants to the elderly, but most deaths occur in adults. Factors or circumstances associated with near-fatal or fatal anaphylaxis are reviewed from the following 10 perspectives: accidents and mishaps, adulterated products, age, allergens, atopy, comorbidities, Munchausen syndrome or contrived anaphylaxis, patient factors, route of administration, and treatment-related issues. There are no absolute contraindications to self-injectable epinephrine, and epinephrine can be administered for anaphylaxis to elderly patients or to those patients receiving beta-adrenergic blockers.
KW - Allergy
KW - Anaphylaxis
KW - Cardiovascular
KW - Fatalities
KW - Histamine
KW - Leukotriene
KW - Prostaglandin
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U2 - 10.1016/j.iac.2015.01.001
DO - 10.1016/j.iac.2015.01.001
M3 - Review article
C2 - 25841558
AN - SCOPUS:84926419373
SN - 0889-8561
VL - 35
SP - 375
EP - 386
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
IS - 2
ER -