Fatal cerebral air embolus complicating multimodality treatment of esophageal cancer

Siva Raja; Thomas W. Rice; David P. Mason; Christina Rodriguez; Carmela Tan; E. Rene Rodriguez; Edward Manno; Gregory M. Videtic; Sudish C. Murthy

doi:10.1016/j.athoracsur.2011.03.054

Fatal cerebral air embolus complicating multimodality treatment of esophageal cancer

Siva Raja, Thomas W. Rice, David P. Mason, Christina Rodriguez, Carmela Tan, E. Rene Rodriguez, Edward Manno, Gregory M. Videtic, Sudish C. Murthy^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A 38-year-old woman with clinical T3N1M0 esophageal adenocarcinoma received an institutional protocol of induction chemotherapy, esophagectomy, and consolidation chemoradiotherapy. Three months after treatment, she had an acute mental status change develop and grand mal seizures. Intracranial imaging demonstrated massive cerebral air emboli, and a rapidly fatal neurologic deterioration ensued. At autopsy, a nonmalignant 0.5-cm gastric conduit to the left atrial fistula was identified. This case illustrates a rare, but fatal, late benign complication of aggressive therapy for locally advanced esophageal cancer.

Original language	English (US)
Pages (from-to)	1901-1903
Number of pages	3
Journal	Annals of Thoracic Surgery
Volume	92
Issue number	5
DOIs	https://doi.org/10.1016/j.athoracsur.2011.03.054
State	Published - Nov 2011

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine
Surgery

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10.1016/j.athoracsur.2011.03.054

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title = "Fatal cerebral air embolus complicating multimodality treatment of esophageal cancer",

abstract = "A 38-year-old woman with clinical T3N1M0 esophageal adenocarcinoma received an institutional protocol of induction chemotherapy, esophagectomy, and consolidation chemoradiotherapy. Three months after treatment, she had an acute mental status change develop and grand mal seizures. Intracranial imaging demonstrated massive cerebral air emboli, and a rapidly fatal neurologic deterioration ensued. At autopsy, a nonmalignant 0.5-cm gastric conduit to the left atrial fistula was identified. This case illustrates a rare, but fatal, late benign complication of aggressive therapy for locally advanced esophageal cancer.",

author = "Siva Raja and Rice, {Thomas W.} and Mason, {David P.} and Christina Rodriguez and Carmela Tan and Rodriguez, {E. Rene} and Edward Manno and Videtic, {Gregory M.} and Murthy, {Sudish C.}",

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AU - Raja, Siva

AU - Rice, Thomas W.

AU - Mason, David P.

AU - Rodriguez, Christina

AU - Tan, Carmela

AU - Rodriguez, E. Rene

AU - Manno, Edward

AU - Videtic, Gregory M.

AU - Murthy, Sudish C.

PY - 2011/11

Y1 - 2011/11

N2 - A 38-year-old woman with clinical T3N1M0 esophageal adenocarcinoma received an institutional protocol of induction chemotherapy, esophagectomy, and consolidation chemoradiotherapy. Three months after treatment, she had an acute mental status change develop and grand mal seizures. Intracranial imaging demonstrated massive cerebral air emboli, and a rapidly fatal neurologic deterioration ensued. At autopsy, a nonmalignant 0.5-cm gastric conduit to the left atrial fistula was identified. This case illustrates a rare, but fatal, late benign complication of aggressive therapy for locally advanced esophageal cancer.

AB - A 38-year-old woman with clinical T3N1M0 esophageal adenocarcinoma received an institutional protocol of induction chemotherapy, esophagectomy, and consolidation chemoradiotherapy. Three months after treatment, she had an acute mental status change develop and grand mal seizures. Intracranial imaging demonstrated massive cerebral air emboli, and a rapidly fatal neurologic deterioration ensued. At autopsy, a nonmalignant 0.5-cm gastric conduit to the left atrial fistula was identified. This case illustrates a rare, but fatal, late benign complication of aggressive therapy for locally advanced esophageal cancer.

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JO - Annals of Thoracic Surgery

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Fatal cerebral air embolus complicating multimodality treatment of esophageal cancer

Abstract

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