Fatal cervical spondyloarthropathy in a hemodialysis patient with systemic deposition of β2-microglobulin amyloid

F. R. Danesh, J. Klinkmann, H. Yokoo, P. Ivanovich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Destructive spondyloarthropathy is a serious complication in patients with end-stage renal disease. We report a case of fatal cervical spondyloarthropathy in a patient on hemodialysis who presented with severe pain in the cervical area. Magnetic resonance imaging (MRI) of the cervical spine showed a soft tissue mass at the cervico-occipital hinge with spinal cord compression and destructive lesions of the cervical vertebrae. The patient became quadriplegic during the MRI procedure and died a few days later. Postmortem examination showed deposition of β2-microglobulin in the cervico-occipital hinge. A unique feature of this case was the dOcUmented presence of systemic β2-microglobulin amyloid deposits involving the spleen that to our knowledge has not been reported previously. Clinical suspicion and early detection of lesions caused by dialysis-related amyloidosis (DRA) may help to prevent significant morbidity and mortality in long-term dialysis patients.

Original languageEnglish (US)
Pages (from-to)563-566
Number of pages4
JournalAmerican Journal of Kidney Diseases
Issue number3
StatePublished - 1999


  • Cervical spondyloarthropathy
  • Dialysis-related amyloidosis
  • Systemic DRA

ASJC Scopus subject areas

  • Nephrology

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