Fatal cytophagic histiocytic panniculitis after a short response to cyclosporine

Joan Guitart*, Ruchi Sethi, Kenneth Gordon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Cytophagic histiocytic panniculitis (CHP) is a disorder characterized by a histiocytic infiltrate in the subcutaneous adipose tissue which often extends to involve systemic organs. Fever, pancytopenia, hepatosplenomegaly, mucosal ulcers and serositis are common systemic symptoms. Although remissions have been reported, the disease tends to follow a chronic course often complicated by terminal hemorrhagic diathesis and death. Several reports in the recent literature have suggested that cyclosporine is the treatment of choice in CHP. We report the first case of cyclosporine treatment failure in CPH. Despite an initial response to treatment and persistent resolution of cutaneous lesions, the internal disease progressed resulting in the patient's death. Therefore the evolution of skin lesions and signs of systemic involvement may not be an accurate assessment of disease activity in patients with CHP being treated with cyclosporine.

Original languageEnglish (US)
Pages (from-to)267-268
Number of pages2
JournalJournal of the European Academy of Dermatology and Venereology
Issue number3
StatePublished - 1998


  • Cyclosporine
  • Cytophagic
  • Panniculitis

ASJC Scopus subject areas

  • Infectious Diseases
  • Dermatology


Dive into the research topics of 'Fatal cytophagic histiocytic panniculitis after a short response to cyclosporine'. Together they form a unique fingerprint.

Cite this