Fatal disseminated adenoviral infection in a renal transplant patient

Hossein Ardehali, Keith Volmar, Caroline Roberts, Michael Forman, Lewis C. Becker*

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Immunosuppressed patients are more susceptible to adenoviral infection and carry a significantly higher mortality than immunocompetent patients. Renal transplant patients with adenoviral infection most often present with infection of the kidney and urinary tract within weeks to months of transplant surgery, suggesting reactivation of the latent adenovirus in the immunosuppressed host as the source of infection. We describe the first case of a fatal adenovirus infection after several years of immunosuppression in a kidney transplant patient. Postmortem examination of several tissues, using standard viral culture and polymerase chain reaction, was positive for adenovirus serotype 21. This case is unusual in that the fatal disseminated viral infection occurred after 6 years of immunosuppression, suggesting that the source of adenovirus was a novel infection rather than reactivation of latent infection, or infection from the transplanted tissue. Furthermore, this is the first report of adenovirus type 21 in an immunosuppressed patient.

Original languageEnglish (US)
Pages (from-to)998-999
Number of pages2
JournalTransplantation
Volume71
Issue number7
DOIs
StatePublished - Apr 15 2001

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Fatal disseminated adenoviral infection in a renal transplant patient'. Together they form a unique fingerprint.

Cite this