Fatal massive hemolysis caused by immunoglobulin M anti-c antibody in a patient with newly diagnosed B-cell acute lymphoblastic leukemia: a case report

Carlos Galvez; Abdulrahman Abutaleb; Wade T. Iams; Paul F. Lindholm; Hau C. Kwaan

doi:10.1002/ccr3.1534

Fatal massive hemolysis caused by immunoglobulin M anti-c antibody in a patient with newly diagnosed B-cell acute lymphoblastic leukemia: a case report

Carlos Galvez, Abdulrahman Abutaleb, Wade T. Iams, Paul F. Lindholm, Hau C. Kwaan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Delayed hemolytic transfusion reactions (DHTRs) occur secondary to slow, mild IgG-mediated processes against minor red blood cell antigens. Herein, we report the case of a rapidly fatal alloimmune anti-c IgM-mediated hemolysis, a rare, previously undescribed, pathophysiologic scenario. Early recognition of such phenomena can expedite supportive measures and optimize patient outcomes.

Original language	English (US)
Pages (from-to)	1090-1093
Number of pages	4
Journal	Clinical Case Reports
Volume	6
Issue number	6
DOIs	https://doi.org/10.1002/ccr3.1534
State	Published - Jun 2018

Keywords

Anti-c antibody
IgM
hemolytic transfusion reaction

ASJC Scopus subject areas

Medicine(all)

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10.1002/ccr3.1534

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title = "Fatal massive hemolysis caused by immunoglobulin M anti-c antibody in a patient with newly diagnosed B-cell acute lymphoblastic leukemia: a case report",

abstract = "Delayed hemolytic transfusion reactions (DHTRs) occur secondary to slow, mild IgG-mediated processes against minor red blood cell antigens. Herein, we report the case of a rapidly fatal alloimmune anti-c IgM-mediated hemolysis, a rare, previously undescribed, pathophysiologic scenario. Early recognition of such phenomena can expedite supportive measures and optimize patient outcomes.",

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Fatal massive hemolysis caused by immunoglobulin M anti-c antibody in a patient with newly diagnosed B-cell acute lymphoblastic leukemia : a case report. / Galvez, Carlos; Abutaleb, Abdulrahman; Iams, Wade T.; Lindholm, Paul F.; Kwaan, Hau C.

In: Clinical Case Reports, Vol. 6, No. 6, 06.2018, p. 1090-1093.

Research output: Contribution to journal › Article › peer-review

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T1 - Fatal massive hemolysis caused by immunoglobulin M anti-c antibody in a patient with newly diagnosed B-cell acute lymphoblastic leukemia

T2 - a case report

AU - Galvez, Carlos

AU - Abutaleb, Abdulrahman

AU - Iams, Wade T.

AU - Lindholm, Paul F.

AU - Kwaan, Hau C.

PY - 2018/6

Y1 - 2018/6

N2 - Delayed hemolytic transfusion reactions (DHTRs) occur secondary to slow, mild IgG-mediated processes against minor red blood cell antigens. Herein, we report the case of a rapidly fatal alloimmune anti-c IgM-mediated hemolysis, a rare, previously undescribed, pathophysiologic scenario. Early recognition of such phenomena can expedite supportive measures and optimize patient outcomes.

AB - Delayed hemolytic transfusion reactions (DHTRs) occur secondary to slow, mild IgG-mediated processes against minor red blood cell antigens. Herein, we report the case of a rapidly fatal alloimmune anti-c IgM-mediated hemolysis, a rare, previously undescribed, pathophysiologic scenario. Early recognition of such phenomena can expedite supportive measures and optimize patient outcomes.

KW - Anti-c antibody

KW - IgM

KW - hemolytic transfusion reaction

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Fatal massive hemolysis caused by immunoglobulin M anti-c antibody in a patient with newly diagnosed B-cell acute lymphoblastic leukemia: a case report

Abstract

Keywords

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