Fatal massive hemolysis caused by immunoglobulin M anti-c antibody in a patient with newly diagnosed B-cell acute lymphoblastic leukemia: a case report

Carlos Galvez, Abdulrahman Abutaleb, Wade T. Iams, Paul F. Lindholm, Hau C. Kwaan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Delayed hemolytic transfusion reactions (DHTRs) occur secondary to slow, mild IgG-mediated processes against minor red blood cell antigens. Herein, we report the case of a rapidly fatal alloimmune anti-c IgM-mediated hemolysis, a rare, previously undescribed, pathophysiologic scenario. Early recognition of such phenomena can expedite supportive measures and optimize patient outcomes.

Original languageEnglish (US)
Pages (from-to)1090-1093
Number of pages4
JournalClinical Case Reports
Volume6
Issue number6
DOIs
StatePublished - Jun 2018

Keywords

  • Anti-c antibody
  • IgM
  • hemolytic transfusion reaction

ASJC Scopus subject areas

  • Medicine(all)

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