Fatal thrombotic thrombocytopenic purpura despite plasmapheresis. A case report of autopsy findings

Hau C. Kwaan*, P. H. Domer

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever and renal dysfunction. Prior to modern therapy, fewer than 3% of patients survived. However, with plasmapheresis, up to 82% of patients survive. We report a case of recurrent TTP which proved fatal despite plasmapheresis. At autopsy the hyaline thrombi found were notably smaller and of shorter duration than those of untreated TTP. These findings suggest that therapy had brought about an abatement of the microthrombotic process in spite of the fatal outcome.

Original languageEnglish (US)
Pages (from-to)344-347
Number of pages4
JournalHaemostasis
Volume19
Issue number6
StatePublished - Jan 1 1989

Keywords

  • plasmapheresis
  • thrombotic microangiopathy
  • thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Hematology

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