Fatal thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus

Fred A. Cecere, Sadyoshi Yoshinoya, Richard M. Pope*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


An immunologic mechanism, possibly immune complex mediated, has been suggested as the basis for the pathogenesis of thrombotic thrombocytopenic purpura (TTP). The evidence supporting this concept has been the association of TTP with systemic lupus erythematosus and the successful therapy of TTP by plasmapheresis. However, most investigators have failed to demonstrate elevated circulating immune complexes during the course of TTP. This report describes a young woman with systemic lupus who developed TTP as a terminal event. Elevated levels of immune complexes were associated with periods of active lupus but were not detectable at the time she developed TTP.

Original languageEnglish (US)
Pages (from-to)550-553
Number of pages4
JournalArthritis & Rheumatism
Issue number3
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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