Fate choice of post-natal mesoderm progenitors: Skeletal versus cardiac muscle plasticity

Domiziana Costamagna, Mattia Quattrocelli, Robin Duelen, Vardine Sahakyan, Ilaria Perini, Giacomo Palazzolo, Maurilio Sampaolesi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.

Original languageEnglish (US)
Pages (from-to)615-627
Number of pages13
JournalCellular and Molecular Life Sciences
Issue number4
StatePublished - Feb 2014


  • Cardiac muscle
  • Lineage switch
  • Muscular dystrophy
  • Myogenic regeneration
  • Resident stem cells
  • Skeletal muscle

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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