TY - JOUR
T1 - Fate choice of post-natal mesoderm progenitors
T2 - Skeletal versus cardiac muscle plasticity
AU - Costamagna, Domiziana
AU - Quattrocelli, Mattia
AU - Duelen, Robin
AU - Sahakyan, Vardine
AU - Perini, Ilaria
AU - Palazzolo, Giacomo
AU - Sampaolesi, Maurilio
N1 - Funding Information:
We ask forgiveness of the authors whose work was not cited here due to space constraints. The Translational Cardiomyology laboratory is supported by CARE-MI FP7, AFM, CARIPLO, FWO, GOA, UIAP and OT grants. We are particularly grateful to Giulio Cossu, Jan Deprest, Paul Holvoet, Danny Huylebroeck, Frank Luyten, Karin Sipido, and Catherine Verfaillie for critical discussions. The authors would also like to thank Christina Vochten and Vicky Raets for professional secretarial service and Paolo Luban and Rondoufonds voor Duchenne Onderzoek for kind donations.
PY - 2014/2
Y1 - 2014/2
N2 - Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.
AB - Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.
KW - Cardiac muscle
KW - Lineage switch
KW - Muscular dystrophy
KW - Myogenic regeneration
KW - Resident stem cells
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=84895093260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895093260&partnerID=8YFLogxK
U2 - 10.1007/s00018-013-1445-7
DO - 10.1007/s00018-013-1445-7
M3 - Review article
C2 - 23949444
AN - SCOPUS:84895093260
SN - 1420-682X
VL - 71
SP - 615
EP - 627
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 4
ER -