Abstract
Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 615-627 |
| Number of pages | 13 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 71 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 2014 |
Funding
We ask forgiveness of the authors whose work was not cited here due to space constraints. The Translational Cardiomyology laboratory is supported by CARE-MI FP7, AFM, CARIPLO, FWO, GOA, UIAP and OT grants. We are particularly grateful to Giulio Cossu, Jan Deprest, Paul Holvoet, Danny Huylebroeck, Frank Luyten, Karin Sipido, and Catherine Verfaillie for critical discussions. The authors would also like to thank Christina Vochten and Vicky Raets for professional secretarial service and Paolo Luban and Rondoufonds voor Duchenne Onderzoek for kind donations.
Keywords
- Cardiac muscle
- Lineage switch
- Muscular dystrophy
- Myogenic regeneration
- Resident stem cells
- Skeletal muscle
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Cellular and Molecular Neuroscience
- Cell Biology