Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?

Hal E. Broxmeyer*, Yan Liu, Reuben Kapur, Christie M. Orschell, Arafat Aljoufi, James P. Ropa, Thao Trinh, Sarah Burns, Maegan L. Capitano

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

There is an ongoing shift in demographics such that older persons will outnumber young persons in the coming years, and with it age-associated tissue attrition and increased diseases and disorders. There has been increased information on the association of the aging process with dysregulation of hematopoietic stem (HSC) and progenitor (HPC) cells, and hematopoiesis. This review provides an extensive up-to date summary on the literature of aged hematopoiesis and HSCs placed in context of potential artifacts of the collection and processing procedure, that may not be totally representative of the status of HSCs in their in vivo bone marrow microenvironment, and what the implications of this are for understanding aged hematopoiesis. This review covers a number of interactive areas, many of which have not been adequately explored. There are still many unknowns and mechanistic insights to be elucidated to better understand effects of aging on the hematopoietic system, efforts that will take multidisciplinary approaches, and that could lead to means to ameliorate at least some of the dysregulation of HSCs and HPCs associated with the aging process. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)1020-1048
Number of pages29
JournalStem Cell Reviews and Reports
Volume16
Issue number6
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • Aging
  • CHIP
  • Cytokines/Chemokines
  • Hematopoiesis
  • Hematopoietic stem and progenitor cells
  • Inflammation
  • Microbiome
  • Microenvironment
  • Oxygen

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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