Fatigue in systemic lupus erythematosus

Grace E. Ahn*, Rosalind Ramsey-Goldman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


Systemic lupus erythematosus is a chronic inflammatory autoimmune disease often characterized by fatigue, with significant effects on physical functioning and wellbeing. The definition, prevalence and factors associated with fatigue, including physical activity, obesity, sleep, depression, anxiety, mood, cognitive dysfunction, vitamin D deficiency/insufficiency, pain, effects of medications and comorbidities, as well as potential therapeutic options of fatigue in the systemic lupus erythematosus population are reviewed. Due to variability in the reliability and validity of various fatigue measures used in clinical studies, clinical trial data have been challenging to interpret. Further investigation into the relationships between these risk factors and fatigue, and improved measures of fatigue, may lead to an improvement in the management of this chronic inflammatory disease.

Original languageEnglish (US)
Pages (from-to)217-227
Number of pages11
JournalInternational Journal of Clinical Rheumatology
Issue number2
StatePublished - Apr 2012


  • anxiety
  • depression
  • fatigue
  • physical activity
  • sleep
  • systemic lupus erythematosus
  • vitamin D

ASJC Scopus subject areas

  • Rheumatology


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