Fatigue in Systemic Lupus Erythematosus and Rheumatoid Arthritis

Rosalind Ramsey-Goldman*, Nan Rothrock

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Abstract: Two inflammatory autoimmune diseases, systemic lupus erythematosus and rheumatoid arthritis, are characterized by fatigue. Patient reports support the significant negative impact of the symptom on functioning and well-being. The prevalence, trajectory, mechanism, and correlates of fatigue in each disease are reviewed. Some disease-focused treatments have demonstrated a reduction in fatigue. However, until recently, clinical trials have not routinely assessed fatigue. Analyses and interpretation of data have been hindered by variability in the reliability and validity of fatigue measures. Empirically based fatigue treatment guidelines are needed in both conditions.

Original languageEnglish (US)
Pages (from-to)384-392
Number of pages9
JournalPM and R
Issue number5
StatePublished - May 2010

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Neurology
  • Clinical Neurology


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