Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study

Zeeshan Butt, Andrea F. DiMartini, Qian Liu, Mary Ann Simpson, Abigail R. Smith, Jarcy Zee, Brenda W. Gillespie, Susan Holtzman, Daniela P Ladner, Kim Olthoff, Robert A. Fisher, Silvia Hafliger, Chris E. Freise, Mercedes Susan Mandell, Averell H. Sherker, Mary Amanda Dew

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Little is known about living liver donors' perceptions of their physical well-being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium. A total of 271 (91%) of 297 eligible donors were interviewed at least once before donation and 3, 6, 12, and 24 months after donation using validated measures when available. Repeated measures regression models were used to identify potential predictors of worse physical outcomes. We found that donors reported more fatigue immediately after surgery that improved by 2 years after donation, but not to predonation levels. A similar pattern was seen across a number of other physical outcomes. Abdominal or back pain and interference from their pain were rated relatively low on average at all study points. However, 21% of donors did report clinically significant pain at some point during postdonation study follow-up. Across multiple outcomes, female donors, donors whose recipients died, donors with longer hospital stays after surgery, and those whose families discouraged donation were at risk for worse physical well-being outcomes. In conclusion, although not readily modifiable, we have identified risk factors that may help identify donors at risk for worse physical outcomes for targeted intervention. Liver Transplantation 00 000–000 2018 AASLD.

Original languageEnglish (US)
Pages (from-to)1221-1232
Number of pages12
JournalLiver Transplantation
Volume24
Issue number9
DOIs
StatePublished - Sep 1 2018

Fingerprint

Living Donors
Liver Transplantation
Fatigue
Cohort Studies
Tissue Donors
Pain
Liver
Back Pain
Abdominal Pain
Length of Stay

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

Cite this

Butt, Zeeshan ; DiMartini, Andrea F. ; Liu, Qian ; Simpson, Mary Ann ; Smith, Abigail R. ; Zee, Jarcy ; Gillespie, Brenda W. ; Holtzman, Susan ; Ladner, Daniela P ; Olthoff, Kim ; Fisher, Robert A. ; Hafliger, Silvia ; Freise, Chris E. ; Mandell, Mercedes Susan ; Sherker, Averell H. ; Dew, Mary Amanda. / Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study. In: Liver Transplantation. 2018 ; Vol. 24, No. 9. pp. 1221-1232.
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title = "Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study",
abstract = "Little is known about living liver donors' perceptions of their physical well-being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium. A total of 271 (91{\%}) of 297 eligible donors were interviewed at least once before donation and 3, 6, 12, and 24 months after donation using validated measures when available. Repeated measures regression models were used to identify potential predictors of worse physical outcomes. We found that donors reported more fatigue immediately after surgery that improved by 2 years after donation, but not to predonation levels. A similar pattern was seen across a number of other physical outcomes. Abdominal or back pain and interference from their pain were rated relatively low on average at all study points. However, 21{\%} of donors did report clinically significant pain at some point during postdonation study follow-up. Across multiple outcomes, female donors, donors whose recipients died, donors with longer hospital stays after surgery, and those whose families discouraged donation were at risk for worse physical well-being outcomes. In conclusion, although not readily modifiable, we have identified risk factors that may help identify donors at risk for worse physical outcomes for targeted intervention. Liver Transplantation 00 000–000 2018 AASLD.",
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Butt, Z, DiMartini, AF, Liu, Q, Simpson, MA, Smith, AR, Zee, J, Gillespie, BW, Holtzman, S, Ladner, DP, Olthoff, K, Fisher, RA, Hafliger, S, Freise, CE, Mandell, MS, Sherker, AH & Dew, MA 2018, 'Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study' Liver Transplantation, vol. 24, no. 9, pp. 1221-1232. https://doi.org/10.1002/lt.25185

Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study. / Butt, Zeeshan; DiMartini, Andrea F.; Liu, Qian; Simpson, Mary Ann; Smith, Abigail R.; Zee, Jarcy; Gillespie, Brenda W.; Holtzman, Susan; Ladner, Daniela P; Olthoff, Kim; Fisher, Robert A.; Hafliger, Silvia; Freise, Chris E.; Mandell, Mercedes Susan; Sherker, Averell H.; Dew, Mary Amanda.

In: Liver Transplantation, Vol. 24, No. 9, 01.09.2018, p. 1221-1232.

Research output: Contribution to journalArticle

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T1 - Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study

AU - Butt, Zeeshan

AU - DiMartini, Andrea F.

AU - Liu, Qian

AU - Simpson, Mary Ann

AU - Smith, Abigail R.

AU - Zee, Jarcy

AU - Gillespie, Brenda W.

AU - Holtzman, Susan

AU - Ladner, Daniela P

AU - Olthoff, Kim

AU - Fisher, Robert A.

AU - Hafliger, Silvia

AU - Freise, Chris E.

AU - Mandell, Mercedes Susan

AU - Sherker, Averell H.

AU - Dew, Mary Amanda

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N2 - Little is known about living liver donors' perceptions of their physical well-being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium. A total of 271 (91%) of 297 eligible donors were interviewed at least once before donation and 3, 6, 12, and 24 months after donation using validated measures when available. Repeated measures regression models were used to identify potential predictors of worse physical outcomes. We found that donors reported more fatigue immediately after surgery that improved by 2 years after donation, but not to predonation levels. A similar pattern was seen across a number of other physical outcomes. Abdominal or back pain and interference from their pain were rated relatively low on average at all study points. However, 21% of donors did report clinically significant pain at some point during postdonation study follow-up. Across multiple outcomes, female donors, donors whose recipients died, donors with longer hospital stays after surgery, and those whose families discouraged donation were at risk for worse physical well-being outcomes. In conclusion, although not readily modifiable, we have identified risk factors that may help identify donors at risk for worse physical outcomes for targeted intervention. Liver Transplantation 00 000–000 2018 AASLD.

AB - Little is known about living liver donors' perceptions of their physical well-being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium. A total of 271 (91%) of 297 eligible donors were interviewed at least once before donation and 3, 6, 12, and 24 months after donation using validated measures when available. Repeated measures regression models were used to identify potential predictors of worse physical outcomes. We found that donors reported more fatigue immediately after surgery that improved by 2 years after donation, but not to predonation levels. A similar pattern was seen across a number of other physical outcomes. Abdominal or back pain and interference from their pain were rated relatively low on average at all study points. However, 21% of donors did report clinically significant pain at some point during postdonation study follow-up. Across multiple outcomes, female donors, donors whose recipients died, donors with longer hospital stays after surgery, and those whose families discouraged donation were at risk for worse physical well-being outcomes. In conclusion, although not readily modifiable, we have identified risk factors that may help identify donors at risk for worse physical outcomes for targeted intervention. Liver Transplantation 00 000–000 2018 AASLD.

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