Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study

Zeeshan Butt*, Andrea F. DiMartini, Qian Liu, Mary Ann Simpson, Abigail R. Smith, Jarcy Zee, Brenda W. Gillespie, Susan Holtzman, Daniela Ladner, Kim Olthoff, Robert A. Fisher, Silvia Hafliger, Chris E. Freise, Mercedes Susan Mandell, Averell H. Sherker, Mary Amanda Dew

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Little is known about living liver donors' perceptions of their physical well-being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult-to-Adult Living Donor Liver Transplantation Cohort Study consortium. A total of 271 (91%) of 297 eligible donors were interviewed at least once before donation and 3, 6, 12, and 24 months after donation using validated measures when available. Repeated measures regression models were used to identify potential predictors of worse physical outcomes. We found that donors reported more fatigue immediately after surgery that improved by 2 years after donation, but not to predonation levels. A similar pattern was seen across a number of other physical outcomes. Abdominal or back pain and interference from their pain were rated relatively low on average at all study points. However, 21% of donors did report clinically significant pain at some point during postdonation study follow-up. Across multiple outcomes, female donors, donors whose recipients died, donors with longer hospital stays after surgery, and those whose families discouraged donation were at risk for worse physical well-being outcomes. In conclusion, although not readily modifiable, we have identified risk factors that may help identify donors at risk for worse physical outcomes for targeted intervention. Liver Transplantation 00 000–000 2018 AASLD.

Original languageEnglish (US)
Pages (from-to)1221-1232
Number of pages12
JournalLiver Transplantation
Volume24
Issue number9
DOIs
StatePublished - Sep 2018

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ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

Cite this

Butt, Z., DiMartini, A. F., Liu, Q., Simpson, M. A., Smith, A. R., Zee, J., Gillespie, B. W., Holtzman, S., Ladner, D., Olthoff, K., Fisher, R. A., Hafliger, S., Freise, C. E., Mandell, M. S., Sherker, A. H., & Dew, M. A. (2018). Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study. Liver Transplantation, 24(9), 1221-1232. https://doi.org/10.1002/lt.25185