Oscillations in the alpha (8-12 Hz), beta (15-35 Hz) and gamma (35-60 Hz) frequency bands are commonly observed in recordings from the primary motor cortex. Coherence analysis based on motor unit spike trains is commonly used to quantify the degree of shared cortical input and the common modulation of motor unit discharge rates between muscles. In this study, intra-muscular coherence is used to investigate the alterations in the neural drive to the First Dorsal Interosseous muscle directly after a fatiguing contraction and following a rest period. An increase in coherence was observed for all frequency bands examined, which was statistically significant within the alpha and beta frequency ranges. There was no consistent difference between the coherence estimates obtained pre-fatigue and those reported after the recovery period. The increase in beta band coherence post-fatigue may indicate increased levels of cortical drive to the motor unit pool. Although the functional significance behind the increase in beta frequency coherence is unclear, it may aid in the coordination of muscle activity to compensate for the decline in the force generating capacity after fatigue.