TY - JOUR
T1 - Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea
AU - Bhushan, Bharat
AU - Khalyfa, Abdelnaby
AU - Spruyt, Karen
AU - Kheirandish-Gozal, Leila
AU - Capdevila, Oscar Sans
AU - Bhattacharjee, Rakesh
AU - Kim, Jinkwan
AU - Keating, Brendan
AU - Hakonarson, Hakon
AU - Gozal, David
N1 - Funding Information:
DG is supported by National Institutes of Health Grants HL-065270 and HL-086662 .
PY - 2011/8
Y1 - 2011/8
N2 - Introduction: Obstructive sleep apnea (OSA) is associated with increased risk for metabolic syndrome in both adults and children. In adults with OSA, serum levels of fatty acid binding protein 4 (FABP4) are elevated and associated with the degree of metabolic insulin resistance, independent of obesity. Therefore, we assessed plasma FABP4 levels and FABP4 allelic variants in obese and non-obese children with and without OSA. Methods: A total of 309 consecutive children ages 5-8. years were recruited. Children were divided into those with OSA and without OSA (NOSA) based on the apnea-hypopnea index (AHI). Subjects were also subdivided into obese (OB) and non-obese (NOB) based on BMI z score. Morning fasting plasma FABP4 levels were assayed using ELISA, and 11 single-nucleotide polymorphisms (SNPs) within the FABP4 region were genotyped. Results: Morning plasma FABP4 levels were increased in all children with OSA, even in NOB children. However, plasma FABP4 levels were strongly associated with BMI z score. Of the 11 SNPs tested, the frequency of rs1054135 (A/G) minor allele (A) was significantly increased in OSA. This SNP was also associated with increased plasma FABP4 levels in both OSA and obese subjects. The minor allele frequency of all other SNPs was similar in OSA and NOSA groups. Conclusions: Childhood obesity and OSA are associated with higher plasma FABP4 levels and thus promote cardiometabolic risk. The presence of selective SNP (e.g., rs1054135) in the FABP4 gene may account for increased plasma FABP4 levels in the context of obesity and OSA in children.
AB - Introduction: Obstructive sleep apnea (OSA) is associated with increased risk for metabolic syndrome in both adults and children. In adults with OSA, serum levels of fatty acid binding protein 4 (FABP4) are elevated and associated with the degree of metabolic insulin resistance, independent of obesity. Therefore, we assessed plasma FABP4 levels and FABP4 allelic variants in obese and non-obese children with and without OSA. Methods: A total of 309 consecutive children ages 5-8. years were recruited. Children were divided into those with OSA and without OSA (NOSA) based on the apnea-hypopnea index (AHI). Subjects were also subdivided into obese (OB) and non-obese (NOB) based on BMI z score. Morning fasting plasma FABP4 levels were assayed using ELISA, and 11 single-nucleotide polymorphisms (SNPs) within the FABP4 region were genotyped. Results: Morning plasma FABP4 levels were increased in all children with OSA, even in NOB children. However, plasma FABP4 levels were strongly associated with BMI z score. Of the 11 SNPs tested, the frequency of rs1054135 (A/G) minor allele (A) was significantly increased in OSA. This SNP was also associated with increased plasma FABP4 levels in both OSA and obese subjects. The minor allele frequency of all other SNPs was similar in OSA and NOSA groups. Conclusions: Childhood obesity and OSA are associated with higher plasma FABP4 levels and thus promote cardiometabolic risk. The presence of selective SNP (e.g., rs1054135) in the FABP4 gene may account for increased plasma FABP4 levels in the context of obesity and OSA in children.
KW - Atherosclerosis
KW - Cholesterol
KW - Gene polymorphisms
KW - Hyperlipidemia
KW - Metabolic syndrome
KW - Sleep apnea
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U2 - 10.1016/j.sleep.2010.12.014
DO - 10.1016/j.sleep.2010.12.014
M3 - Article
C2 - 21664182
AN - SCOPUS:79960630916
VL - 12
SP - 666
EP - 671
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
IS - 7
ER -