Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea

Bharat Bhushan, Abdelnaby Khalyfa, Karen Spruyt, Leila Kheirandish-Gozal, Oscar Sans Capdevila, Rakesh Bhattacharjee, Jinkwan Kim, Brendan Keating, Hakon Hakonarson, David Gozal*

*Corresponding author for this work

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Introduction: Obstructive sleep apnea (OSA) is associated with increased risk for metabolic syndrome in both adults and children. In adults with OSA, serum levels of fatty acid binding protein 4 (FABP4) are elevated and associated with the degree of metabolic insulin resistance, independent of obesity. Therefore, we assessed plasma FABP4 levels and FABP4 allelic variants in obese and non-obese children with and without OSA. Methods: A total of 309 consecutive children ages 5-8. years were recruited. Children were divided into those with OSA and without OSA (NOSA) based on the apnea-hypopnea index (AHI). Subjects were also subdivided into obese (OB) and non-obese (NOB) based on BMI z score. Morning fasting plasma FABP4 levels were assayed using ELISA, and 11 single-nucleotide polymorphisms (SNPs) within the FABP4 region were genotyped. Results: Morning plasma FABP4 levels were increased in all children with OSA, even in NOB children. However, plasma FABP4 levels were strongly associated with BMI z score. Of the 11 SNPs tested, the frequency of rs1054135 (A/G) minor allele (A) was significantly increased in OSA. This SNP was also associated with increased plasma FABP4 levels in both OSA and obese subjects. The minor allele frequency of all other SNPs was similar in OSA and NOSA groups. Conclusions: Childhood obesity and OSA are associated with higher plasma FABP4 levels and thus promote cardiometabolic risk. The presence of selective SNP (e.g., rs1054135) in the FABP4 gene may account for increased plasma FABP4 levels in the context of obesity and OSA in children.

Original languageEnglish (US)
Pages (from-to)666-671
Number of pages6
JournalSleep Medicine
Volume12
Issue number7
DOIs
StatePublished - Aug 2011

Keywords

  • Atherosclerosis
  • Cholesterol
  • Gene polymorphisms
  • Hyperlipidemia
  • Metabolic syndrome
  • Sleep apnea

ASJC Scopus subject areas

  • Medicine(all)

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    Bhushan, B., Khalyfa, A., Spruyt, K., Kheirandish-Gozal, L., Capdevila, O. S., Bhattacharjee, R., Kim, J., Keating, B., Hakonarson, H., & Gozal, D. (2011). Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea. Sleep Medicine, 12(7), 666-671. https://doi.org/10.1016/j.sleep.2010.12.014