Fatty acid ethyl ester synthesis by the isolated perfused rat heart

Wanlin Chang, Carl Waltenbaugh, Jayme Borensztajn

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Fatty acid ethyl esters (FAEEs), nonoxidative by-products of ethanol metabolism, are found in various tissues and plasma after ethanol ingestion and may be responsible for some of the pathological changes observed in alcohol-consuming individuals. Previous studies demonstrated that several different enzymes, including lipoprotein lipase (LPL), can catalyze FAEE synthesis in vitro. We report that LPL cetalyzes FAEE synthesis in isolated rat hearts perfused with chylomicrons in the presence of ethanol. Most of the FAEEs accumulated in the perfusate, suggesting that in vivo, plasma FAEEs derive from LPL-mediated synthesis. Our results are the first demonstration of the direct involvement of a specific enzyme, LPL, in FAEE synthesis under physiological conditions.

Original languageEnglish (US)
Pages (from-to)926-929
Number of pages4
JournalMetabolism: Clinical and Experimental
Volume46
Issue number8
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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