Fatty acid ethyl ester synthesis by the isolated perfused rat heart

Wanlin Chang; Carl Waltenbaugh; Jayme Borensztajn

doi:10.1016/S0026-0495(97)90081-0

Fatty acid ethyl ester synthesis by the isolated perfused rat heart

Wanlin Chang, Carl Waltenbaugh, Jayme Borensztajn

Pathology

Research output: Contribution to journal › Article

22 Scopus citations

Abstract

Fatty acid ethyl esters (FAEEs), nonoxidative by-products of ethanol metabolism, are found in various tissues and plasma after ethanol ingestion and may be responsible for some of the pathological changes observed in alcohol-consuming individuals. Previous studies demonstrated that several different enzymes, including lipoprotein lipase (LPL), can catalyze FAEE synthesis in vitro. We report that LPL cetalyzes FAEE synthesis in isolated rat hearts perfused with chylomicrons in the presence of ethanol. Most of the FAEEs accumulated in the perfusate, suggesting that in vivo, plasma FAEEs derive from LPL-mediated synthesis. Our results are the first demonstration of the direct involvement of a specific enzyme, LPL, in FAEE synthesis under physiological conditions.

Original language	English (US)
Pages (from-to)	926-929
Number of pages	4
Journal	Metabolism: Clinical and Experimental
Volume	46
Issue number	8
DOIs	https://doi.org/10.1016/S0026-0495(97)90081-0
State	Published - Jan 1 1997

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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Chang, W., Waltenbaugh, C., & Borensztajn, J. (1997). Fatty acid ethyl ester synthesis by the isolated perfused rat heart. Metabolism: Clinical and Experimental, 46(8), 926-929. https://doi.org/10.1016/S0026-0495(97)90081-0

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AB - Fatty acid ethyl esters (FAEEs), nonoxidative by-products of ethanol metabolism, are found in various tissues and plasma after ethanol ingestion and may be responsible for some of the pathological changes observed in alcohol-consuming individuals. Previous studies demonstrated that several different enzymes, including lipoprotein lipase (LPL), can catalyze FAEE synthesis in vitro. We report that LPL cetalyzes FAEE synthesis in isolated rat hearts perfused with chylomicrons in the presence of ethanol. Most of the FAEEs accumulated in the perfusate, suggesting that in vivo, plasma FAEEs derive from LPL-mediated synthesis. Our results are the first demonstration of the direct involvement of a specific enzyme, LPL, in FAEE synthesis under physiological conditions.

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