Favorable outcome of neonatal aortic thrombosis and renovascular hypertension

Michael S. Caplan, Richard A Cohn, Craig Langman*, James A. Conway, Arnold Shkolnik, Robert T. Brouillette

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Fifteen children with renovascular hypertension as a result of aortic thrombosis were followed for a mean of 26 months (range 5 to 58 months) to determine outcome. As neonates, all patients had hyperiension and elevated plasma renin activity. Of 11 patients studied with radionuclide renography and scintigraphy, 10 had abnormal renal blood flow; three had complete absence of unilateral perfusion. On follow-up examination all children were normotensive; five children ages 5 to 24 months required antihypertensive medication. Of 15 children, 14 had normal statural growth; all had normal serum creatinine, plasma renin activity, and calculated glomerular filtration rate values. Patients with complete absence of renal perfusion unllaterally remained functionally anephric; children with less severe perfusion deficits had improved perfusion as shown by radionuclide renography and scintigraphy. We believe that many patients with aortic thrombosis and renovascular hypertension who have had aggressive antihypertensive therapy in the neonatal period will have good renal function and increased perfusion to the affected kidney 2 years later.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalThe Journal of Pediatrics
Volume115
Issue number2
DOIs
StatePublished - Jan 1 1989

Fingerprint

Renovascular Hypertension
Thrombosis
Perfusion
Radioisotope Renography
Kidney
Renin
Radioisotopes
Radionuclide Imaging
Antihypertensive Agents
Renal Circulation
Glomerular Filtration Rate
Creatinine
Newborn Infant
Growth
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Caplan, Michael S. ; Cohn, Richard A ; Langman, Craig ; Conway, James A. ; Shkolnik, Arnold ; Brouillette, Robert T. / Favorable outcome of neonatal aortic thrombosis and renovascular hypertension. In: The Journal of Pediatrics. 1989 ; Vol. 115, No. 2. pp. 291-295.
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Favorable outcome of neonatal aortic thrombosis and renovascular hypertension. / Caplan, Michael S.; Cohn, Richard A; Langman, Craig; Conway, James A.; Shkolnik, Arnold; Brouillette, Robert T.

In: The Journal of Pediatrics, Vol. 115, No. 2, 01.01.1989, p. 291-295.

Research output: Contribution to journalArticle

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