Favorable outcome of neonatal aortic thrombosis and renovascular hypertension

Michael S. Caplan, Richard A. Cohn, Craig B. Langman*, James A. Conway, Arnold Shkolnik, Robert T. Brouillette

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Fifteen children with renovascular hypertension as a result of aortic thrombosis were followed for a mean of 26 months (range 5 to 58 months) to determine outcome. As neonates, all patients had hyperiension and elevated plasma renin activity. Of 11 patients studied with radionuclide renography and scintigraphy, 10 had abnormal renal blood flow; three had complete absence of unilateral perfusion. On follow-up examination all children were normotensive; five children ages 5 to 24 months required antihypertensive medication. Of 15 children, 14 had normal statural growth; all had normal serum creatinine, plasma renin activity, and calculated glomerular filtration rate values. Patients with complete absence of renal perfusion unllaterally remained functionally anephric; children with less severe perfusion deficits had improved perfusion as shown by radionuclide renography and scintigraphy. We believe that many patients with aortic thrombosis and renovascular hypertension who have had aggressive antihypertensive therapy in the neonatal period will have good renal function and increased perfusion to the affected kidney 2 years later.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalThe Journal of pediatrics
Issue number2
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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