Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis

S. Vulliemoz; F. Lurati-Ruiz; F. X. Borruat; J. Delavelle; I. J. Koralnik; T. Kuntzer; J. Bogousslavsky; F. Picard; T. Landis; R. A. Du Pasquier

doi:10.1136/jnnp.2006.092353

Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis

S. Vulliemoz, F. Lurati-Ruiz, F. X. Borruat, J. Delavelle, I. J. Koralnik, T. Kuntzer, J. Bogousslavsky, F. Picard, T. Landis, R. A. Du Pasquier^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT _2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.

Original language	English (US)
Pages (from-to)	1079-1082
Number of pages	4
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	77
Issue number	9
DOIs	https://doi.org/10.1136/jnnp.2006.092353
State	Published - Sep 2006

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ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Surgery

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10.1136/jnnp.2006.092353

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Vulliemoz, S., Lurati-Ruiz, F., Borruat, F. X., Delavelle, J., Koralnik, I. J., Kuntzer, T., Bogousslavsky, J., Picard, F., Landis, T., & Du Pasquier, R. A. (2006). Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis. Journal of Neurology, Neurosurgery and Psychiatry, 77(9), 1079-1082. https://doi.org/10.1136/jnnp.2006.092353

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title = "Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis",

abstract = "Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT 2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.",

author = "S. Vulliemoz and F. Lurati-Ruiz and Borruat, {F. X.} and J. Delavelle and Koralnik, {I. J.} and T. Kuntzer and J. Bogousslavsky and F. Picard and T. Landis and {Du Pasquier}, {R. A.}",

year = "2006",

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Vulliemoz, S, Lurati-Ruiz, F, Borruat, FX, Delavelle, J, Koralnik, IJ, Kuntzer, T, Bogousslavsky, J, Picard, F, Landis, T & Du Pasquier, RA 2006, 'Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis', Journal of Neurology, Neurosurgery and Psychiatry, vol. 77, no. 9, pp. 1079-1082. https://doi.org/10.1136/jnnp.2006.092353

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T1 - Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis

AU - Vulliemoz, S.

AU - Lurati-Ruiz, F.

AU - Borruat, F. X.

AU - Delavelle, J.

AU - Koralnik, I. J.

AU - Kuntzer, T.

AU - Bogousslavsky, J.

AU - Picard, F.

AU - Landis, T.

AU - Du Pasquier, R. A.

PY - 2006/9

Y1 - 2006/9

N2 - Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT 2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.

AB - Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT 2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.

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Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis

Abstract

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