Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis

S. Vulliemoz, F. Lurati-Ruiz, F. X. Borruat, J. Delavelle, I. J. Koralnik, T. Kuntzer, J. Bogousslavsky, F. Picard, T. Landis, R. A. Du Pasquier*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT 2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.

Original languageEnglish (US)
Pages (from-to)1079-1082
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume77
Issue number9
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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