Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT 2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Neurology, Neurosurgery and Psychiatry|
|State||Published - Sep 2006|
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health