Feasibility and construct validity of PROMIS and "legacy" instruments in an academic scleroderma clinic

Dinesh Khanna*, Paul Maranian, Nan Rothrock, David Cella, Richard Gershon, Puja P. Khanna, Brennan Spiegel, Daniel E. Furst, Phil J. Clements, Amber Bechtel, Ron D. Hays

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Objective: The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) roadmap initiative is a cooperative group program of research designed to develop, evaluate, and standardize item banks to measure patient-reported outcomes relevant across medical conditions. The objective of the current study was to assess feasibility and evaluation of the construct validity of PROMIS item banks versus legacy measures in an observational study in systemic sclerosis (SSc). We hypothesized that the PROMIS item banks can be administered in a clinical setting if there is adequate staff support without disrupting the flow of clinic. Methods: Patients with SSc in a single academic center completed computerized adaptive test (CAT) administered PROMIS item banks during the clinic visit and legacy measures (using paper and pencil). The construct validity of PROMIS items was evaluated by examining correlations with corresponding legacy measures using multitrait-multimethod analysis. Results: Participants consisted of 143 SSc patients with an average age of 51.5 years; 71% were female and 68% were white. The average number of items completed for each CAT-administered item bank ranged from 5 to 8 (69 CAT items per patient), and the average time to complete each CAT-administered item bank ranged from 48 seconds to 1.9 minutes per patient (average time = 11.9 minutes/per patient for 11 banks). All correlations between PROMIS domains and respective legacy measures were large and in the hypothesized direction (ranged from 0.61 to 0.82). Conclusion: Our study supports the construct validity of the CAT-administered PROMIS item banks and shows that they can be administered successfully in a clinic with support staff. Future studies should assess the feasibility of PROMIS item banks in a busy clinical practice.

Original languageEnglish (US)
Pages (from-to)128-134
Number of pages7
JournalValue in Health
Volume15
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • PROMIS
  • construct validity
  • health-related quality of life
  • systemic sclerosis

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health

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